Electrophotocatalytic C-H Hydroxyalkylation of Heteroaromatics with Aldehydes

被引：22

作者：

Bi, Huihua ^{[1
]}

Zhou, Yu ^{[1
]}

Jiang, Wei ^{[1
]}

Liu, Jie ^{[1
,2
]}

机构：

[1] Hunan Univ, Coll Chem & Chem Engn, Hunan Prov Key Lab Biomacromol Chem Biol, Changsha 410082, Hunan, Peoples R China

[2] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2022年 / 364卷 / 10期

关键词：

Electrophotocatalysis; Hydroxyalkylation; Minisci reaction; Radical coupling; Heteroaromatics; DECATUNGSTATE ANION; MINISCI REACTION; FUNCTIONALIZATION; ELECTROCHEMISTRY; PHOTOCATALYSIS; SUBSTITUTIONS; GREEN;

D O I：

10.1002/adsc.202200055

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Herein a radical hydroxyalkylation of N-heteroaromatics with aldehydes is reported. The constructive merging of photochemistry and electrochemistry is the key for the success of this atom-economical Minisci method. This protocol highlights the utility of electrophotocatalysis to promote a practical and general synthesis of secondary alcohols in good yields from readily available N-heteroaromatics and aldehydes under mild reaction condition.

引用

页码：1732 / 1737

页数：6

共 57 条

[1] Synthetic Photoelectrochemistry [J].

Barham, Joshua P. ;

Koenig, Burkhard .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 59 (29) :11732-11747

[2]

Barham P., 2020, ANGEW CHEM-GER EDIT, V132, P11828

[3]

Bieszczad B., 2019, ANGEW CHEM, V131, P17034, DOI DOI 10.1002/ANGE.201910641

[4] Photochemical C-H Hydroxyalkylation of Quinolines and Isoquinolines [J].

Bieszczad, Bartosz ;

Perego, Luca Alessandro ;

Melchiorre, Paolo .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 58 (47) :16878-16883

[5]

Brown R., 2011, Design for flooding

[6]

CAPALDO L, 2019, ANGEW CHEM, V131, P17670

[7] Merging Photocatalysis with Electrochemistry: The Dawn of a new Alliance in Organic Synthesis [J].

Capaldo, Luca ;

Quadri, Lorenzo L. ;

Ravelli, Davide .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 58 (49) :17508-17510

[8]

Cornils B., 2018, Applied Homogeneous Catalysis with Organometallic Compounds: A Comprehensive Handbook in Four Volumes, VThird

[9] Palladium-Catalyzed Minisci Reaction with Simple Alcohols [J].

Correia, Camille A. ;

Yang, Luo ;

Li, Chao-Jun .

ORGANIC LETTERS, 2011, 13 (17) :4581-4583

[10] Recent Advances in Visible-Light-Mediated Minisci Reactions [J].

Dong, Jianyang ;

Liu, Yuxiu ;

Wang, Qingmin .

CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 41 (10) :3771-3791

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