A NEW ROUTE FOR THE SYNTHESIS OF SUBSTITUTED 5-AMINO-4-CYANOIMIDAZOL-2-ONES - PRECURSORS FOR THE PREPARATION OF 3,6,7,9-TETRAHYDRO-8H-PURIN-8-ONES DERIVATIVES

被引:4
作者
Chumachenko, S. A. [1 ]
Shablykin, O. V. [1 ]
Kozachenko, A. P.
Osadchuk, T. V.
Brovarets, V. S. [1 ]
机构
[1] Natl Acad Sci Ukraine, Inst Bioorgan Chem & Petrochem, UA-02660 Kiev, Ukraine
关键词
5-alkyl(aryl)amino-2-oxoimidazole-4-thioamides; 5-alkyl(aryl)amino-4-cyanoimidazol-2-ones; 2-alkoxycarbonylamino-3,3-dichloroacrylonitriles; 3,6,7,9-tetrahydro-8H-purin-8-ones; triethyl orthoformate; heterocyclization; RECEPTOR ANTAGONISTS; BIOLOGICAL-ACTIVITY; 3-METHYLISOGUANOSINE; AMINES; FURIN;
D O I
10.1007/s10593-011-0762-8
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
5-Alkyl(aryl)amino-4-cyanoimidazol-2-ones were obtained on the basis of 2-alkoxycarbonylamino-3,3-dichloroacrylonitriles. They were then used for the synthesis of derivatives of 3,6,7,9-tetrahydro-8H-purin-8-ones.
引用
收藏
页码:336 / 341
页数:6
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