A NEW ROUTE FOR THE SYNTHESIS OF SUBSTITUTED 5-AMINO-4-CYANOIMIDAZOL-2-ONES - PRECURSORS FOR THE PREPARATION OF 3,6,7,9-TETRAHYDRO-8H-PURIN-8-ONES DERIVATIVES

被引：4

作者：

Chumachenko, S. A. ^{[1
]}

Shablykin, O. V. ^{[1
]}

Kozachenko, A. P.

Osadchuk, T. V.

Brovarets, V. S. ^{[1
]}

机构：

[1] Natl Acad Sci Ukraine, Inst Bioorgan Chem & Petrochem, UA-02660 Kiev, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2011年 / 47卷 / 03期

关键词：

5-alkyl(aryl)amino-2-oxoimidazole-4-thioamides; 5-alkyl(aryl)amino-4-cyanoimidazol-2-ones; 2-alkoxycarbonylamino-3,3-dichloroacrylonitriles; 3,6,7,9-tetrahydro-8H-purin-8-ones; triethyl orthoformate; heterocyclization; RECEPTOR ANTAGONISTS; BIOLOGICAL-ACTIVITY; 3-METHYLISOGUANOSINE; AMINES; FURIN;

D O I：

10.1007/s10593-011-0762-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5-Alkyl(aryl)amino-4-cyanoimidazol-2-ones were obtained on the basis of 2-alkoxycarbonylamino-3,3-dichloroacrylonitriles. They were then used for the synthesis of derivatives of 3,6,7,9-tetrahydro-8H-purin-8-ones.

引用

页码：336 / 341

页数：6

共 22 条

[1] AGRAWAL VK, 1981, INDIAN J CHEM B, V20, P398
[2] Purin-8-ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists
Beck, JP
Arvanitis, AG
Curry, MA
Rescinito, JT
Fitzgerald, LW
Gilligan, PJ
Zaczek, R
Trainor, GL
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (07) : 967 - 972
[3] Subtilase-like pro-protein convertases: from molecular specificity to therapeutic applications
Bergeron, F
Leduc, R
Day, R
[J]. JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2000, 24 (01) : 1 - 22
[4] BIANCHI M, 1983, EUR J MED CHEM, V18, P501
[5] Brovarets V. S., 1999, ZH OBSHCH KHIM, V69, P1646
[6] Rational design of novel immunosuppressive drugs: Analogues of azathioprine lacking the 6-mercaptopurine substituent retain or have enhanced immunosuppressive effects
Crawford, DJK
Maddocks, JL
Jones, DN
Szawlowski, P
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (14) : 2690 - 2695
[7] DIELS O, 1910, BER, V43, P3317
[8] DIELS O, 1909, BER, V42, P4068
[9] DRACH BS, 1973, ZH ORG KHIM+, V9, P1818
[10] DRACH BS, 1974, ZH ORG KHIM+, V10, P1271

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