Insula shows abnormal task-evoked and resting-state activity in first-episode drug-naive generalized anxiety disorder

被引：35

作者：

Cui, Huiru ^{[1
]}

Zhang, Bin ^{[2
,3
]}

Li, Wei ^{[1
]}

Li, Hui ^{[1
]}

Pang, Jiaoyan ^{[1
]}

Hu, Qiang ^{[1
]}

Zhang, Lanlan ^{[4
]}

Tang, Yingying ^{[1
]}

Yang, Zhi ^{[1
]}

Wang, Jijun ^{[1
,7
]}

Li, Chunbo ^{[1
,5
,6
,7
]}

Northoff, Georg ^{[8
,9
,10
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, 600 Wan Ping Nan Rd, Shanghai 200030, Peoples R China

[2] Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Guangzhou, Peoples R China

[3] Guangdong Engn Technol Res Ctr Translat Med Ment, Guangzhou, Peoples R China

[4] Suzhou Guangji Hosp, Suzhou, Peoples R China

[5] Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai, Peoples R China

[6] Shanghai Jiao Tong Univ, Brain Sci & Technol Res Ctr, Shanghai, Peoples R China

[7] Shanghai Jiao Tong Univ, Inst Psychol & Behav Sci, Shanghai, Peoples R China

[8] Univ Ottawa, Inst Mental Hlth Res, Ottawa, ON, Canada

[9] Hangzhou Normal Univ, Ctr Cognit & Brain Disorders, Hangzhou, Peoples R China

[10] Zhejiang Univ, Sch Med, Mental Hlth Ctr, Hangzhou, Zhejiang, Peoples R China

来源：

DEPRESSION AND ANXIETY | 2020年 / 37卷 / 07期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

anxiety; awareness; functional connectivity; functional magnetic resonance imaging (fMRI); generalized anxiety disorder; insula; interoception; FUNCTIONAL CONNECTIVITY; INTEROCEPTIVE AWARENESS; FMRI; PERCEPTION; BODY; INDIVIDUALS; RESPONSES; AROUSAL; CORTEX; SCALE;

D O I：

10.1002/da.23009

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Background Interoception is associated with neural activity in the insula of healthy humans. On the basis of the somatic symptoms in generalized anxiety disorder (GAD), especially abnormal heartbeat perception, we hypothesized that abnormal activity in the insula was associated with interoceptive awareness in patients with GAD. Methods We investigated the psychological correlates of interoceptive awareness in a sample of 34 patients with first-onset, drug-naive GAD and 30 healthy controls (HCs). Furthermore, we compared blood oxygenation level-dependent responses between the two groups during a heartbeat perception task to assess task-evoked activity and its relationship with psychological measures. We also examined between-group differences in insular subregions resting-state functional connectivity (rsFC), and its relationship with anxiety severity. Results Patients with GAD had significantly higher body perception scores than HCs. They also exhibited greater task-evoked activity in the left anterior insula, left posterior insula, and right anterior insula during interoceptive awareness than HCs. Left anterior insula activity was positively correlated with body awareness in patients with GAD, and rsFC between the left anterior insula and left medial prefrontal gyrus was negatively correlated with somatic anxiety severity. Conclusions Investigating a sample of first-episode, drug-naive patients, our study demonstrated abnormal interoceptive awareness in patients with GAD and that this was related to abnormal anterior insular activity during both rest and task. These results shed new light on the psychological and neural substrates of somatic symptoms in GAD, and they may serve to establish abnormal interoceptive awareness as a neural and psychological marker of GAD.

引用

页码：632 / 644

页数：13

共 59 条

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