Studies on antitumor mechanism of two planar platinum(II) complexes with 8-hydroxyquinoline: Synthesis, characterization, cytotoxicity, cell cycle and apoptosis

被引：89
作者：
Qin, Qi-Pin [1 ]
Chen, Zhen-Feng [1 ]
Qin, Jiao-Lan [1 ]
He, Xiao-Ju [1 ]
Li, Yu-Lan [1 ]
Liu, Yan-Cheng [1 ]
Huang, Ke-Bin [1 ]
Liang, Hong [1 ]
机构：
[1] Guangxi Normal Univ, Sch Pharm & Chem, State Key Lab Cultivat Base Chem & Mol Engn Med R, Guilin 541004, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2015年 / 92卷
关键词：
8-Hydroxyquinoline; 8-Hydroxy-2-methylquinoline; Pt(II) complexes; Crystal structure; Cytotoxicity; Cells apoptosis; IN-VITRO; COPPER(II) COMPLEXES; CRYSTAL-STRUCTURE; DNA INTERACTION; ANTIPROLIFERATIVE ACTIVITY; DERIVATIVES; CLIOQUINOL; CLEAVAGE; P53; ACTIVATION;
D O I：
10.1016/j.ejmech.2014.12.052
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[Pt(Q)(2)] (I) and [Pt(MQ)(2)] (2) exhibited enhanced cytotoxicity against BEL-7404, Hep-G2, NCI-H460, T-24, A549 tumor cells but low cytotoxicity on normal HL-7702 cells. 1 and 2 could cause the cell cycle arrest in G2 and S phase, respectively. While pifithrin-alpha, a specific p53 inhibitor, induced cell cycle arrest in G1 phase. Although 1, 2 and pifithrin-alpha caused serious inhibition on p53,1 and 2 significantly cause the loss of mitochondrial membrane potential and increase of the reactive oxygen species level, cytochrome c, apaf-1 and caspase-3/9 ratio in BEL-7404 cells. 1 and 2 may trigger the cell apoptosis through a mitochondrial dysfunction pathway whereas pifithrin-alpha does not. The interactions of 1 and 2 with DNA are most probably via an intercalation. (C) 2014 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：302 / 313
页数：12
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