Studies on antitumor mechanism of two planar platinum(II) complexes with 8-hydroxyquinoline: Synthesis, characterization, cytotoxicity, cell cycle and apoptosis

被引：89
作者：
Qin, Qi-Pin [1 ]
Chen, Zhen-Feng [1 ]
Qin, Jiao-Lan [1 ]
He, Xiao-Ju [1 ]
Li, Yu-Lan [1 ]
Liu, Yan-Cheng [1 ]
Huang, Ke-Bin [1 ]
Liang, Hong [1 ]
机构：
[1] Guangxi Normal Univ, Sch Pharm & Chem, State Key Lab Cultivat Base Chem & Mol Engn Med R, Guilin 541004, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2015年 / 92卷
关键词：
8-Hydroxyquinoline; 8-Hydroxy-2-methylquinoline; Pt(II) complexes; Crystal structure; Cytotoxicity; Cells apoptosis; IN-VITRO; COPPER(II) COMPLEXES; CRYSTAL-STRUCTURE; DNA INTERACTION; ANTIPROLIFERATIVE ACTIVITY; DERIVATIVES; CLIOQUINOL; CLEAVAGE; P53; ACTIVATION;
D O I：
10.1016/j.ejmech.2014.12.052
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[Pt(Q)(2)] (I) and [Pt(MQ)(2)] (2) exhibited enhanced cytotoxicity against BEL-7404, Hep-G2, NCI-H460, T-24, A549 tumor cells but low cytotoxicity on normal HL-7702 cells. 1 and 2 could cause the cell cycle arrest in G2 and S phase, respectively. While pifithrin-alpha, a specific p53 inhibitor, induced cell cycle arrest in G1 phase. Although 1, 2 and pifithrin-alpha caused serious inhibition on p53,1 and 2 significantly cause the loss of mitochondrial membrane potential and increase of the reactive oxygen species level, cytochrome c, apaf-1 and caspase-3/9 ratio in BEL-7404 cells. 1 and 2 may trigger the cell apoptosis through a mitochondrial dysfunction pathway whereas pifithrin-alpha does not. The interactions of 1 and 2 with DNA are most probably via an intercalation. (C) 2014 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：302 / 313
页数：12
相关论文
共 65 条
[1]  
Arango D, 2001, CANCER RES, V61, P4910
[2]   THERMAL UNFOLDING OF A GROUP-I RIBOZYME - THE LOW-TEMPERATURE TRANSITION IS PRIMARILY DISRUPTION OF TERTIARY STRUCTURE [J].
BANERJEE, AR ;
JAEGER, JA ;
TURNER, DH .
BIOCHEMISTRY, 1993, 32 (01) :153-163
[3]   DNA minor groove binders as potential antitumor and antimicrobial agents [J].
Baraldi, PG ;
Bovero, A ;
Fruttarolo, F ;
Preti, D ;
Tabrizi, MA ;
Pavani, MG ;
Romagnoli, R .
MEDICINAL RESEARCH REVIEWS, 2004, 24 (04) :475-528
[4]   Oxidative Stress Induced by Copper and Iron Complexes with 8-Hydroxyquinoline Derivatives Causes Paraptotic Death of HeLa Cancer Cells [J].
Barilli, Amelia ;
Atzeri, Corrado ;
Bassanetti, Irene ;
Ingoglia, Filippo ;
Dall'Asta, Valeria ;
Bussolati, Ovidio ;
Maffini, Monica ;
Mucchino, Claudio ;
Marchio, Luciano .
MOLECULAR PHARMACEUTICS, 2014, 11 (04) :1151-1163
[5]   Neuroprotective Copper Bis(thiosemicarbazonato) Complexes Promote Neurite Elongation [J].
Bica, Laura ;
Liddell, Jeffrey R. ;
Donnelly, Paul S. ;
Duncan, Clare ;
Caragounis, Aphrodite ;
Volitakis, Irene ;
Paterson, Brett M. ;
Cappai, Roberto ;
Grubman, Alexandra ;
Camakaris, James ;
Crouch, Peter J. ;
White, Anthony R. .
PLOS ONE, 2014, 9 (02)
[6]   A Glutathione Derivative with Chelating and in vitro Neuroprotective Activities: Synthesis, Physicochemical Properties, and Biological Evaluation [J].
Cacciatore, Ivana ;
Cornacchia, Catia ;
Fornasari, Erika ;
Baldassarre, Leonardo ;
Pinnen, Francesco ;
Sozio, Piera ;
Di Stefano, Antonio ;
Marinelli, Lisa ;
Dean, Annalisa ;
Fulle, Stefania ;
Di Filippo, Ester Sara ;
La Rovere, Rita Maria Laura ;
Patruno, Antonia ;
Ferrone, Alessio ;
Di Marco, Valerio .
CHEMMEDCHEM, 2013, 8 (11) :1818-1829
[7]   Membrane Localized Iridium(III) Complex Induces Endoplasmic Reticulum Stress and Mitochondria-Mediated Apoptosis in Human Cancer Cells [J].
Cao, Rui ;
Jia, Junli ;
Ma, Xiaochuan ;
Zhou, Ming ;
Fei, Hao .
JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (09) :3636-3644
[8]   Casiopeina III-ia induces apoptosis in HCT-15 cells in vitro through caspase-dependent mechanisms and has antitumor effect in vivo [J].
Carvallo-Chaigneau, Francisco ;
Trejo-Solis, Cristina ;
Gomez-Ruiz, Celedonio ;
Rodriguez-Aguilera, Ernesto ;
Macias-Rosales, Lucia ;
Cortes-Barberena, Edith ;
Cedillo-Pelaez, Carlos ;
Gracia-Mora, Isabel ;
Ruiz-Azuara, Lena ;
Madrid-Marina, Vicente ;
Constantino-Casas, Fernando .
BIOMETALS, 2008, 21 (01) :17-28
[9]   Copper Chelator Induced Efficient Episodic Memory Recovery in a Non-Transgenic Alzheimer's Mouse Model [J].
Ceccom, Johnatan ;
Cosledan, Frederic ;
Halley, Helene ;
Frances, Bernard ;
Lassalle, Jean Michel ;
Meunier, Bernard .
PLOS ONE, 2012, 7 (08)
[10]   Ruthenium Polyaminocarboxylate Complexes PROSPECTS FOR THEIR USE AS METALLOPHARMACEUTICALS [J].
Chatterjee, Debabrata ;
Mitra, Anannya ;
De, G. S. .
PLATINUM METALS REVIEW, 2006, 50 (01) :2-11
1234567