Nuclear apoptosis contributes to sarcopenia

被引：107

作者：

Alway, Stephen E. ^{[1
]}

Siu, Parco M. ^{[2
]}

机构：

[1] W Virginia Univ, Robert C Byrd Hlth Sci Ctr, Sch Med, Div Exercise Physiol,Lab Muscle Biol & Sarcopenia, Morgantown, WV 26506 USA

[2] Hong Kong Polytech Univ, Dept Hlth Technol & Informat, Kowloon, Hong Kong, Peoples R China

来源：

EXERCISE AND SPORT SCIENCES REVIEWS | 2008年 / 36卷 / 02期

关键词：

atrophy; mitochondria; skeletal myofiber; satellite cells; signaling proteins;

D O I：

10.1097/JES.0b013e318168e9dc

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Apoptosis results in DNA fragmentation and, subsequently, destruction of cells containing a single nucleus. Our hypothesis is that multinucleated cells such as muscle fibers can experience apoptotic-induced loss of single nuclei (nuclear apoptosis) without destruction of the entire fiber. The loss of nuclei likely contributes to atrophy and sarcopenia. Furthermore, increased chronic activity attenuates apoptotic signaling, which may reduce sarcopenia.

引用

页码：51 / 57

页数：7

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