Mechanisms for the Resolution of Organ Fibrosis

被引：97

作者：

Horowitz, Jeffrey C. ^{[1
]}

Thannickal, Victor J. ^{[2
]}

机构：

[1] Univ Michigan, Dept Internal Med, Div Pulm & Crit Care Med, Med Sch, Ann Arbor, MI 48109 USA

[2] Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USA

来源：

PHYSIOLOGY | 2019年 / 34卷 / 01期

基金：

美国国家卫生研究院;

关键词：

IDIOPATHIC PULMONARY-FIBROSIS; FOCAL ADHESION KINASE; HEPATIC STELLATE CELLS; NEWLY SYNTHESIZED COLLAGEN; LIVER FIBROSIS; LYSYL OXIDASE; MYOFIBROBLAST DIFFERENTIATION; GROWTH-FACTOR; I COLLAGEN; LUNG FIBROSIS;

D O I：

10.1152/physiol.00033.2018

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Fibrosis is a dynamic process with the potential for reversibility and restoration of near-normal tissue architecture and organ function. Herein, we review mechanisms for resolution of organ fibrosis, in particular that involving the lung, with an emphasis on the critical roles of myofibroblast apoptosis and clearance of deposited matrix.

引用

页码：43 / 55

页数：13

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