Antimicrobial peptides and pregnancy

被引：68
作者：
Frew, Lorraine [1 ]
Stock, Sarah J. [1 ]
机构：
[1] Univ Edinburgh, Queens Med Res Inst, MRC Ctr Reprod Hlth, Edinburgh EH16 4TJ, Midlothian, Scotland
来源：
REPRODUCTION | 2011年 / 141卷 / 06期
基金：
英国惠康基金;
关键词：
LEUKOCYTE PROTEASE INHIBITOR; ELASTASE-SPECIFIC INHIBITOR; FEMALE REPRODUCTIVE-TRACT; HUMAN BETA-DEFENSINS; AMINO-ACID-SEQUENCE; PROTEINASE-INHIBITOR; AMNIOTIC-FLUID; EPITHELIAL-CELLS; HUMAN BETA-DEFENSIN-2; FETAL MEMBRANES;
D O I：
10.1530/REP-10-0537
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Antimicrobial peptides (AMPs) are small proteins produced by epithelial surfaces and inflammatory cells, which have broad-spectrum antimicrobial and immunomodulatory activities. They are known to be important in a number of infectious and inflammatory conditions and have been shown to be present in a number of sites throughout the female reproductive tract. Inflammation and infection are associated with a number of complications of pregnancy including preterm labor, and AMPs may play a key role in maintaining and protecting pregnancy. The aim of this review is to describe the expression and function of AMPs in the pregnant female reproductive tract and their relation to preterm labor. Reproduction (2011) 141 725-735
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收藏
页码：725 / 735
页数：11
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