Electrochemistry of chalcogen compounds: prediction of antioxidant activity

被引：47
作者：
Giles, GI
Tasker, KM
Johnson, RJK
Jacob, C
Peers, C
Green, KN
机构：
[1] Univ Exeter, Sch Chem, Exeter EX4 4QD, Devon, England
[2] Univ Leeds, Inst Cardiovasc Res, Leeds LS2 9JT, W Yorkshire, England
来源：
CHEMICAL COMMUNICATIONS | 2001年 / 23期
关键词：
D O I：
10.1039/b107972g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Synthesis and characterisation of organochalcogens has demonstrated a high correlation between their electrochemical oxidation potential on the glassy carbon electrode, their activity in bioassays and an unprecedented antioxidant activity in neuronal cell culture (EC50 similar to 20 nM) making electrochemical methodology a valuable tool in drug design for Alzheimer's and related diseases.
引用
收藏
页码：2490 / 2491
页数：2
相关论文
共 21 条
[1]   ANTIOXIDANT ACTIVITY OF SOME DIARYLSELENIDES IN BIOLOGICAL-SYSTEMS [J].
ANDERSSON, CM ;
HALLBERG, A ;
LINDEN, M ;
BRATTSAND, R ;
MOLDEUS, P ;
COTGREAVE, I .
FREE RADICAL BIOLOGY AND MEDICINE, 1994, 16 (01) :17-28
[2]   THE CORRELATION OF THE OXIDATION POTENTIALS OF STRUCTURALLY RELATED DIBENZO[1,4]DICHALCOGENINES TO THEIR ANTIOXIDANTE CAPACITY IN BIOLOGICAL-SYSTEMS UNDERGOING FREE RADICAL-INDUCED LIPID-PEROXIDATION [J].
COTGREAVE, IA ;
MOLDEUS, P ;
ENGMAN, L ;
HALLBERG, A .
BIOCHEMICAL PHARMACOLOGY, 1991, 42 (07) :1481-1485
[3]   SYNTHESIS, ANTIOXIDANT PROPERTIES, BIOLOGICAL-ACTIVITY AND MOLECULAR MODELING OF A SERIES OF CHALCOGEN ANALOGS OF THE 5-LIPOXYGENASE INHIBITOR DUP-654 [J].
ENGMAN, L ;
STERN, D ;
FRISELL, H ;
VESSMAN, K ;
BERGLUND, M ;
EK, B ;
ANDERSSON, CM .
BIOORGANIC & MEDICINAL CHEMISTRY, 1995, 3 (09) :1255-1262
[4]   MILD REDUCTION OF TELLURIUM(IV) AND SELENIUM(IV) COMPOUNDS BY SODIUM ASCORBATE [J].
ENGMAN, L ;
PERSSON, J .
SYNTHETIC COMMUNICATIONS, 1993, 23 (04) :445-458
[5]   IMPROVED PREPARATION OF DIARYL DITELLURIDES [J].
ENGMAN, L ;
PERSSON, J .
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1990, 388 (1-2) :71-74
[6]   THIOL PEROXIDASE-ACTIVITY OF DIARYL DITELLURIDES AS DETERMINED BY A H-1-NMR METHOD [J].
ENGMAN, L ;
STERN, D ;
COTGREAVE, IA ;
ANDERSSON, CM .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (25) :9737-9743
[7]   APPLICATION OF THE HAMMETT EQUATION TO THE ELECTROCHEMICAL OXIDATION OF DIARYL CHALCOGENIDES AND ARYL METHYL CHALCOGENIDES [J].
ENGMAN, L ;
PERSSON, J ;
ANDERSSON, CM ;
BERGLUND, M .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1992, (08) :1309-1313
[8]   Hypothesis: The role of reactive sulfur species in oxidative stress [J].
Giles, GI ;
Tasker, KM ;
Jacob, C .
FREE RADICAL BIOLOGY AND MEDICINE, 2001, 31 (10) :1279-1283
[9]   Amyloid β peptides mediate hypoxic augmentation of Ca2+ channels [J].
Green, KN ;
Peers, C .
JOURNAL OF NEUROCHEMISTRY, 2001, 77 (03) :953-956
[10]   A MODEL STUDY ON THE EFFECT OF AN AMINO GROUP ON THE ANTIOXIDANT ACTIVITY OF GLUTATHIONE-PEROXIDASE [J].
IWAOKA, M ;
TOMODA, S .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (06) :2557-2561
123