Fluorine-modified bisbenzimide derivative as a molecular probe for bimodal and simultaneous detection of DNAs by 19F NMR and fluorescence

被引：20

作者：

Sakamoto, Takashi ^{[1
]}

Hasegawa, Daisaku ^{[1
]}

Fujimoto, Kenzo ^{[1
,2
]}

机构：

[1] Japan Adv Inst Sci & Technol, Sch Mat Sci, Nomi, Ishikawa 9231292, Japan

[2] Japan Adv Inst Sci & Technol, Res Ctr Bioarchitecture, Nomi, Ishikawa 9231292, Japan

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 42期

关键词：

PROTEIN-DETECTION; NANOPROBES;

D O I：

10.1039/c5cc01995h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

3,5-Bis(trifluoromethyl) benzene modified bisbenzimide H 33258 was synthesized as a F-19 magnetic resonance-based DNA detection probe. The chemical shift and fluorescence of the probe were significantly changed by the addition of hairpin DNAs having an AATT sequence. The probe enables F-19 NMR/fluorescence bimodal detection of the model DNA double strands simultaneously.

引用

页码：8749 / 8752

页数：4

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