Gene polymorphisms and transplantation

被引：60
作者：
Akalin, E [1 ]
Murphy, B [1 ]
机构：
[1] Mt Sinai Sch Med, Div Renal, New York, NY 10029 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 05期
关键词：
D O I：
10.1016/S0952-7915(00)00261-2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The influence of gene polymorphisms in key immunoregulatory molecules on the clinical course post-transplant has become an area of active research, since it offers a possible explanation for the heterogeneity in outcomes between individuals. Several groups have now investigated the association of polymorphisms in molecules - including cytokines, cytokine receptors, adhesion molecules and costimulatory molecules that participate in the immune response to an allograft. Several interesting observations have been made that would suggest that genetic variability influencing allograft survival reaches beyond that of the MHC molecules.
引用
收藏
页码：572 / 576
页数：5
相关论文
共 36 条
[1]   Analysis of the polymorphism of the tumour necrosis factor (TNF) gene and promoter and of circulating TNF-alpha levels in heart-transplant patients suffering or not suffering from severe rejection [J].
Abdallah, AN ;
Cucchi-Mouillot, P ;
Biteau, N ;
Cassaigne, A ;
Haras, D ;
Iron, A .
EUROPEAN JOURNAL OF IMMUNOGENETICS, 1999, 26 (04) :249-255
[2]   CA repeat allele polymorphism in the first intron of the human interferon-γ gene is associated with lung allograft fibrosis [J].
Awad, M ;
Pravica, V ;
Perrey, C ;
El Gamel, A ;
Yonan, N ;
Sinnott, PJ ;
Hutchinson, IV .
HUMAN IMMUNOLOGY, 1999, 60 (04) :343-346
[3]   Genotypic variation in the transforming growth factor-β1 gene -: Association with transforming growth factor-pi production, fibrotic lung disease, and graft fibrosis after lung transplantation [J].
Awad, MR ;
El-Gamel, A ;
Hasleton, P ;
Turner, DM ;
Sinnott, PJ ;
Hutchinson, IV .
TRANSPLANTATION, 1998, 66 (08) :1014-1020
[4]   Renal failure after clinical heart transplantation is associated with the TGF-β1 codon 10 gene polymorphism [J].
Baan, CC ;
Balk, AHMM ;
Holweg, CTJ ;
van Riemsdijk, IC ;
Maat, LPWM ;
Vantrimpont, PJMJ ;
Niesters, HGM ;
Weimar, W .
JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2000, 19 (09) :866-872
[5]   Correlation between angiotensin-converting enzyme gene insertion/deletion polymorphism and kidney graft long-term outcome in pediatric recipients - A single-center analysis [J].
Barocci, S ;
Ginevri, F ;
Valente, U ;
Torre, F ;
Gusmano, R ;
Nocera, A .
TRANSPLANTATION, 1999, 67 (04) :534-538
[6]   The effect of polymorphisms in tumor necrosis factor-α, interleukin-10, and transforming growth factor-β1 genes in acute hepatic allograft rejection [J].
Bathgate, AJ ;
Pravica, V ;
Perrey, C ;
Theraponods, G ;
Plevris, JN ;
Hayes, PC ;
Hutchinson, IV .
TRANSPLANTATION, 2000, 69 (07) :1514-1517
[7]  
Beige J, 1999, J AM SOC NEPHROL, V10, P1717
[8]   Identification of ICAM-1 polymorphism that is associated with protection from transplant associated vasculopathy after cardiac transplantation [J].
Borozdenkova, S ;
Smith, J ;
Marshall, S ;
Yacoub, M ;
Rose, M .
HUMAN IMMUNOLOGY, 2001, 62 (03) :247-255
[9]   Secretion of tumour necrosis factor alpha and lymphotoxin alpha in relation to polymorphisms in the TNF genes and HLA-DR alleles. Relevance for inflammatory bowel disease [J].
Bouma, G ;
Crusius, JBA ;
Pool, MO ;
Kolkman, JJ ;
VonBlomberg, BME ;
Kostense, PJ ;
Giphart, MJ ;
Schreuder, GMT ;
Meuwissen, SGM ;
Pena, AS .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1996, 43 (04) :456-463
[10]   Recipient tumor necrosis factor-α and interleukin-10 gene polymorphisms associate with early mortality and acute graft-versus-host disease severity in HLA-matched sibling bone marrow transplants [J].
Cavet, J ;
Middleton, PG ;
Segall, M ;
Noreen, H ;
Davies, SM ;
Dickinson, AM .
BLOOD, 1999, 94 (11) :3941-3946
1234