Gastric cancer stem-like cells possess higher capability of invasion and metastasis in association with a mesenchymal transition phenotype

被引：101
作者：
Yang, Lang [1 ,2 ]
Ping, Yi-Fang [1 ,2 ]
Yu, Xi [1 ,2 ]
Qian, Feng [3 ]
Guo, Zheng-Jun [1 ,2 ]
Qian, Cheng [1 ,2 ]
Cui, You-Hong [1 ,2 ]
Bian, Xiu-Wu [1 ,2 ]
机构：
[1] Third Mil Med Univ, Inst Pathol, Southwest Hosp, Chongqing 400038, Peoples R China
[2] Third Mil Med Univ, SW Canc Ctr, Southwest Hosp, Chongqing 400038, Peoples R China
[3] Third Mil Med Univ, Dept Gen Surg, Southwest Hosp, Chongqing 400038, Peoples R China
来源：
CANCER LETTERS | 2011年 / 310卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Gastric cancer; Cancer stem cells; Sphere-forming cells; Invasion; GLIOMA-CELLS; IDENTIFICATION; EXPRESSION; CARCINOMA; GLIOBLASTOMA; POPULATION; MATRIX-METALLOPROTEINASE-9; INVASIVENESS; EXPANSION; TUMORS;
D O I：
10.1016/j.canlet.2011.06.003
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancer stem cells have been isolated from various types of cancer including leukemia and solid tumors. However, the methods for isolating gastric cancer stem-like cells (GCSCs) have not been well established. As a consequence, the biological behavior and the significance of these cells to cancer progression remains to be clarified. In this study, we isolated and characterized GCSCs from a gastric cancer cell line SGC7901 and found their enhanced capabilities of invasion in vitro and metastasis in vivo. We further studied the expression of molecules related to epithelial-mesenchymal and invasion in GCSCs and found there were decreased E-cadherin, but increased vimentin and matrix metalloproteinase 2 (MMP-2), in these cells. Our results suggest that decreased E-cadherin and increased MMP-2 may be associated with the capacity of GCSCs to metastasize. (C) 2011 Published by Elsevier Ireland Ltd.
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页码：46 / 52
页数：7
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