Increased burden of illness associated with antimicrobial-resistant Salmonella enterica serotype typhimurium infections

被引:111
作者
Martin, LJ
Fyfe, M
Doré, K
Buxton, JA
Pollari, F
Henry, B
Middleton, D
Ahmed, R
Jamieson, F
Ciebin, B
McEwen, SA
Wilson, JB
机构
[1] Hlth Canada, Foodborne Waterborne & Zoonot Infect Div, Lab Ctr Dis Control, Field Epidemiol Training Program, Guelph, ON N1G 5B2, Canada
[2] Hlth Canada, Div EnterFoodborne & Waterborne Dis, Guelph, ON N1G 5B2, Canada
[3] Univ Guelph, Dept Populat Med, Guelph, ON N1G 2W1, Canada
[4] Ontario Minist Hlth & Long Term Care, Toronto, ON, Canada
[5] Hlth Canada, Natl Lab Enter Pathogens, Winnipeg, MB, Canada
[6] British Columbia Ctr Dis Control, Vancouver, BC, Canada
关键词
D O I
10.1086/381270
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
This study investigated the burden of illness associated with 440 cases of Salmonella enterica serotype Typhimurium infection identified in Canada between December 1999 and November 2000. We categorized case subjects' infections by definitive phage type 104 (DT104) and antimicrobial-resistance patterns. These variables were then investigated as risk factors for hospitalization. Hospitalization was more likely to occur among case subjects whose infections were resistant to at least ampicillin, chloramphenicol and/or kanamycin, streptomycin, sulphamethoxazole, and tetracycline (R-type AK/CSSuT; odds ratio [OR], 2.3; P = .003), compared with case subjects with AK/CSSuT-susceptible infections, and among case subjects with non-DT104 R-type AKSSuT infections (OR, 3.6; P = .005), compared with case subjects with non-DT104 AKSSuT-susceptible infections. In contrast, hospitalization rates did not differ between case subjects with DT104 infections and case subjects with non-DT104 infections or between case subjects with DT104 R-type ACSSuT infections and case subjects with DT104 ACSSuT-susceptible infections. We estimated that 57% of the hospitalizations among AK/CSSuT case subjects and 72% of the hospitalizations among non-DT104 AKSSuT case subjects were attributable to the resistance patterns of the infections.
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页码:377 / 384
页数:8
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