Cancer protective effects of plums: A systematic review

被引:22
作者
Bahrin, Abdul Alim [1 ]
Moshawih, Said [1 ]
Dhaliwal, Jagjit Singh [1 ]
Kanakal, Mahibub Mahahamadsa [2 ]
Khan, Abdullah [3 ]
Lee, Kah Seng [4 ]
Goh, Bey Hing [5 ,6 ]
Goh, Hui Poh [1 ]
Kifli, Nurolaini [1 ]
Ming, Long Chiau [1 ]
机构
[1] Univ Brunei Darussalam, PAP Rashidah Saadatul Bolkiah Inst Hlth Sci, Jalan Tungku Link, BE-1410 Gadong, Brunei
[2] Quest Int Univ, Fac Pharm, Ipoh, Perak, Malaysia
[3] KPJ Healthcare Univ Coll, Sch Pharm, Nilai, Negeri Sembilan, Malaysia
[4] Univ Cyberjaya, Fac Pharm, Cyberjaya, Selangor, Malaysia
[5] Monash Univ Malaysia, Sch Pharm, Biofunct Mol Exploratory BMEX Res Grp, Bandar Sunway, Malaysia
[6] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou, Peoples R China
关键词
Plum; Cancer; Review; Prunus domestica; Prunus salicina; Antioxidant; TOTAL ANTIOXIDANT CAPACITY; PRUNUS-DOMESTICA; IN-VITRO; PHENOLIC-COMPOUNDS; IMMATURE PLUM; CV SOLDAM; POLYPHENOLS; APOPTOSIS; PEACH; FRUITS;
D O I
10.1016/j.biopha.2021.112568
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Plums is one of the most cultivated stone fruits due to its fast growing popularity. It has various traditionally recognized health benefits. There are two main commercial types of plums: the European plum (Prunus domestica) and the Japanese plum (Prunus salicina), each having many varieties. Researchers are gathering further evidence of pharmacological effects for plums by scientifically studying its anti-inflammatory, antioxidant properties. A systematic review analysing the literature related to the effects of plums on prevention and treatment of cancer is warranted. This is the first review examining the cancer-related effects of plums. Antioxidation properties of the active constituents of plum were also compared. Scopus, Google Scholar, PubMed, Medxriv and Cochrane Library databases, from their date of inception until July 2021 were utilized. The risk of bias was assessed using CONSORT checklist. A total of 6639 studies were screened and eventually only 54 studies were included. Full-text review of included studies revealed that plum extracts were rich in antioxidants. Overall, most of the studies that fulfilled the eligibility criteria were in vitro and a few clinical studies involving in vivo work. Therefore, it would be beneficial to perform more studies on animals or humans, to confirm that the result obtained from these in vitro studies are able to be extrapolated in a wider range of applications. Further clinical and in vivo studies are warranted to validate plums as a functional food for treatment and prevention of cancer.
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页数:17
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