19F Oximetry with semifluorinated alkanes

被引：4

作者：

Kegel, Stefan ^{[1
]}

Chacon-Caldera, Jorge ^{[2
]}

Tsagogiorgas, Charalambos ^{[3
]}

Theisinger, Bastian ^{[4
]}

Glatting, Gerhard ^{[1
]}

Schad, Lothar R. ^{[2
]}

机构：

[1] Heidelberg Univ, Univ Med Mannheim, Med Fac Mannheim, Med Radiat Phys Radiat Protect, Mannheim, Germany

[2] Heidelberg Univ, Univ Med Mannheim, Med Fac Mannheim, Comp Assisted Clin Med, Mannheim, Germany

[3] Heidelberg Univ, Univ Med Mannheim, Med Fac Mannheim, Dept Anaesthesiol & Surg Intens Care Med, Mannheim, Germany

[4] Novaliq GmbH, Heidelberg, Germany

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2016年 / 44卷 / 08期

关键词：

19F; alkane; fluorine; hexafluorobenzene; hypoxia; MRI; oxygen; relaxation; semifluorinated; semifluorinated alkanes; TISSUE OXYGEN-TENSION; BLOOD-SUBSTITUTES; PERFLUOROCARBON; SPECTROSCOPY; HYPOXIA; PERFLUORO-15-CROWN-5-ETHER; HEXAFLUOROBENZENE; TEMPERATURE; EMULSIONS; CARRIERS;

D O I：

10.3109/21691401.2015.1111228

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

This work examines the variation of longitudinal relaxation rate R1(=1/T1) of the F-19-CF3-resonance of semifluorinated alkanes (SFAs) with oxygen tension (pO(2)), temperature (T) and pH in vitro. Contrary to their related perfluorocarbons (PFCs), SFA are amphiphilic and facilitate stable emulsions, a prerequisite for clinical use. A linear relationship between R1 and pO(2) was confirmed for the observed SFAs at different temperatures. Using a standard saturation recovery sequence, T1 has been successfully measured using fluorine F-19-MRI with a self-constructed birdcage resonator at 9.4T. A calibration curve to calculate pO(2) depending on T and R1 was found for each SFA used. In contrast to the commonly used PFC, SFAs are less sensitive to changes in pO(2), but more sensitive to changes in temperature. The influence of pH to R1 was found to be negligible.

引用

页码：1861 / 1866

页数：6

共 33 条

[1] OXYGEN-TENSION MAPPING WITH F-19 ECHO-PLANAR MR-IMAGING OF SEQUESTERED PERFLUOROCARBON [J].

BARKER, BR ;

MASON, RP ;

BANSAL, N ;

PESHOCK, RM .

JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING, 1994, 4 (04) :595-602

[2]

Bellemann M E, 2002, Biomed Tech (Berl), V47 Suppl 1 Pt 1, P451, DOI 10.1515/bmte.2002.47.s1a.451

[3] RAPID TISSUE OXYGEN-TENSION MAPPING USING F-19 INVERSION-RECOVERY ECHO-PLANAR IMAGING OF PERFLUORO-15-CROWN-5-ETHER [J].

DARDZINSKI, BJ ;

SOTAK, CH .

MAGNETIC RESONANCE IN MEDICINE, 1994, 32 (01) :88-97

[4] Non-invasive multiparametric qBOLD approach for robust mapping of the oxygen extraction fraction [J].

Domsch, Sebastian ;

Mie, Moritz B. ;

Wenz, Frederik ;

Schad, Lothar R. .

ZEITSCHRIFT FUR MEDIZINISCHE PHYSIK, 2014, 24 (03) :231-242

[5] A New Paradigm for High-Sensitivity 19F Magnetic Resonance Imaging of Perfluorooctylbromide [J].

Giraudeau, Celine ;

Flament, Julien ;

Marty, Benjamin ;

Boumezbeur, Fawzi ;

Meriaux, Sebastien ;

Robic, Caroline ;

Port, Marc ;

Tsapis, Nicolas ;

Fattal, Elias ;

Giacomini, Eric ;

Lethimonnier, Franck ;

Le Bihan, Denis ;

Valette, Julien .

MAGNETIC RESONANCE IN MEDICINE, 2010, 63 (04) :1119-1124

[6]

Graves EE, 2007, ONCOLOGY-NY, V21, P368

[7]

Graves EE, 2007, ONCOLOGY WILLISTON P, V21, P384

[8]

Graves EE, 2007, ONCOLOGY WILLISTON P, V21, P377

[9] Imaging hypoxia to improve radiotherapy outcome [J].

Horsman, Michael R. ;

Mortensen, Lise Sakso ;

Petersen, Jorgen B. ;

Busk, Morten ;

Overgaard, Jens .

NATURE REVIEWS CLINICAL ONCOLOGY, 2012, 9 (12) :674-687

[10] Physical principles of quantitative nuclear magnetic resonance oximetry [J].

Kodibagkar, Vikram D. ;

Wang, Xianghui ;

Mason, Ralph P. .

FRONTIERS IN BIOSCIENCE-LANDMARK, 2008, 13 :1371-1384

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