Influence of Placental Mannose/N-Acetyl Glucosamine-Binding Proteins on the Interaction of Insulin and Insulin-Like Growth Factors with Their Receptors
Placenta is a source of carbohydrate-binding proteins that function as molecular scavengers, but they could also be involved in interactions that assist in metabolic control. Mannose/N-acetyl-glucosamine (Man/GlcNAc)-binding proteins from placenta were isolated and their reactivity towards placental insulin and insulin-like growth factor receptors (IR and IGF-Rs) was analyzed. The lectins reduced the binding of insulin and IGF-I in a dose-dependent manner, while almost no effect was observed on the binding of IGF-II. The shape of the inhibition curves changed, suggesting altered binding specificity. The presence of sugar could not reverse completely the effect of the lectins, implicating both lectin-sugar and protein-protein conformational recognition. Since biological molecules in our experimental system were those that are in close relation in vivo, placental Man/GlcNAc-specific lectins may be regarded as potential allosteric modulators of ligand-receptor interactions in a system of homologous ligands, selectively affecting only binding to tyrosine kinase type receptors (IR and IGF-1R).
机构:
Genentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USAGenentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USA
Keck, Rodney
Nayak, Namita
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Regulatory Affairs Dept, San Francisco, CA USAGenentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USA
Nayak, Namita
Lerner, Laura
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USAGenentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USA
Lerner, Laura
Raju, Shanta
论文数: 0引用数: 0
h-index: 0
机构:
Centocor R&D Inc, Radnor, PA USAGenentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USA
Raju, Shanta
Ma, Stacey
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Pharmaceut Dev Dept, San Francisco, CA USAGenentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USA
Ma, Stacey
Schreitmueller, Thomas
论文数: 0引用数: 0
h-index: 0
机构:
F Hoffman La Roche AG, Analyt R&D & Quality Control Biotech Prod, CH-4070 Basel, SwitzerlandGenentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USA
Schreitmueller, Thomas
Chamow, Stephen
论文数: 0引用数: 0
h-index: 0
机构:Genentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USA
Chamow, Stephen
Moorhouse, Kathy
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Analyt Technol, San Francisco, CA USAGenentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USA
Moorhouse, Kathy
Kotts, Claire
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Bioanalyt Technol, San Francisco, CA USAGenentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USA
Kotts, Claire
Jones, Andrew
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USAGenentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USA
机构:
Univ Arizona, Physiol Sci Grad Interdisciplinary Program, Tucson, AZ 85724 USA
Univ Arizona, Sarver Heart Ctr, Tucson, AZ 85724 USAUniv Arizona, Dept Surg, Tucson, AZ 85724 USA
La Bonte, Laura R.
Dokken, Betsy
论文数: 0引用数: 0
h-index: 0
机构:
Univ Arizona, Physiol Sci Grad Interdisciplinary Program, Tucson, AZ 85724 USA
Univ Arizona, Sarver Heart Ctr, Tucson, AZ 85724 USAUniv Arizona, Dept Surg, Tucson, AZ 85724 USA
Dokken, Betsy
Davis-Gorman, Grace
论文数: 0引用数: 0
h-index: 0
机构:
Univ Arizona, Dept Surg, Tucson, AZ 85724 USA
Univ Arizona, Sarver Heart Ctr, Tucson, AZ 85724 USAUniv Arizona, Dept Surg, Tucson, AZ 85724 USA
机构:
Univ Arizona, Dept Surg, Tucson, AZ 85724 USA
Univ Arizona, Physiol Sci Grad Interdisciplinary Program, Tucson, AZ 85724 USA
Univ Arizona, Sarver Heart Ctr, Tucson, AZ 85724 USAUniv Arizona, Dept Surg, Tucson, AZ 85724 USA
机构:
Genentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USAGenentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USA
Keck, Rodney
Nayak, Namita
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Regulatory Affairs Dept, San Francisco, CA USAGenentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USA
Nayak, Namita
Lerner, Laura
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USAGenentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USA
Lerner, Laura
Raju, Shanta
论文数: 0引用数: 0
h-index: 0
机构:
Centocor R&D Inc, Radnor, PA USAGenentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USA
Raju, Shanta
Ma, Stacey
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Pharmaceut Dev Dept, San Francisco, CA USAGenentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USA
Ma, Stacey
Schreitmueller, Thomas
论文数: 0引用数: 0
h-index: 0
机构:
F Hoffman La Roche AG, Analyt R&D & Quality Control Biotech Prod, CH-4070 Basel, SwitzerlandGenentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USA
Schreitmueller, Thomas
Chamow, Stephen
论文数: 0引用数: 0
h-index: 0
机构:Genentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USA
Chamow, Stephen
Moorhouse, Kathy
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Analyt Technol, San Francisco, CA USAGenentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USA
Moorhouse, Kathy
Kotts, Claire
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Bioanalyt Technol, San Francisco, CA USAGenentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USA
Kotts, Claire
Jones, Andrew
论文数: 0引用数: 0
h-index: 0
机构:
Genentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USAGenentech Inc, Analyt Dev Dept, San Francisco, CA 94080 USA
机构:
Univ Arizona, Physiol Sci Grad Interdisciplinary Program, Tucson, AZ 85724 USA
Univ Arizona, Sarver Heart Ctr, Tucson, AZ 85724 USAUniv Arizona, Dept Surg, Tucson, AZ 85724 USA
La Bonte, Laura R.
Dokken, Betsy
论文数: 0引用数: 0
h-index: 0
机构:
Univ Arizona, Physiol Sci Grad Interdisciplinary Program, Tucson, AZ 85724 USA
Univ Arizona, Sarver Heart Ctr, Tucson, AZ 85724 USAUniv Arizona, Dept Surg, Tucson, AZ 85724 USA
Dokken, Betsy
Davis-Gorman, Grace
论文数: 0引用数: 0
h-index: 0
机构:
Univ Arizona, Dept Surg, Tucson, AZ 85724 USA
Univ Arizona, Sarver Heart Ctr, Tucson, AZ 85724 USAUniv Arizona, Dept Surg, Tucson, AZ 85724 USA
机构:
Univ Arizona, Dept Surg, Tucson, AZ 85724 USA
Univ Arizona, Physiol Sci Grad Interdisciplinary Program, Tucson, AZ 85724 USA
Univ Arizona, Sarver Heart Ctr, Tucson, AZ 85724 USAUniv Arizona, Dept Surg, Tucson, AZ 85724 USA