Combating Acanthamoeba spp. cysts: what are the options?

被引：53

作者：

Anwar, Ayaz ^{[1
]}

Khan, Naveed Ahmed ^{[1
]}

Siddiqui, Ruqaiyyah ^{[1
]}

机构：

[1] Sunway Univ, Sch Sci & Technol, Dept Biol Sci, Subang Jaya, Malaysia

来源：

PARASITES & VECTORS | 2018年 / 11卷

关键词：

Acanthamoeba; Cyst; Encystation; Excystation; Therapeutic targets; IN-VITRO; KERATITIS; CASTELLANII; NANOPARTICLES; INFECTIONS; DIFFERENTIATION; ENCEPHALITIS; TROPHOZOITES; EXPRESSION; ENCYSTMENT;

D O I：

10.1186/s13071-017-2572-z

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Acanthamoeba spp. are protist pathogens and causative agents of serious infections including keratitis and granulomatous amoebic encephalitis. Its ability to convert into dormant and highly resistant cysts form limits effectiveness of available therapeutic agents and presents a pivotal challenge for drug development. During the cyst stage, Acanthamoeba is protected by the presence of hardy cyst walls, comprised primarily of carbohydrates and cyst-specific proteins, hence synthesis inhibition and/or degradation of cyst walls is of major interest. This review focuses on targeting of Acanthamoeba cysts by identifying viable therapeutic targets.

引用

页数：6

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