Roles of programmed cell death protein 5 in inflammation and cancer (Review)

被引：20
作者：
Wang, Wei [1 ]
Song, Xiao-Wen [1 ]
Zhao, Cheng-Hai [1 ]
机构：
[1] China Med Univ, Dept Pathophysiol, Coll Basic Med Sci, Shenyang 110122, Liaoning, Peoples R China
来源：
INTERNATIONAL JOURNAL OF ONCOLOGY | 2016年 / 49卷 / 05期
关键词：
programmed cell death 5; inflammation; cancer; p53; P-glycoprotein; CISPLATIN-INDUCED APOPTOSIS; IN-VITRO; CELL-DEATH-5; PROTEIN; REDUCED EXPRESSION; DISEASE-ACTIVITY; SYNOVIAL-FLUID; ANTITUMOR ROLE; PDCD5; GENE; INVOLVEMENT;
D O I：
10.3892/ijo.2016.3706
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
PDCD5 (programmed cell death 5) is an apoptosis related gene cloned in 1999 from a human leukemic cell line. PDCD5 protein containing 125 amino acid (aa) residues sharing significant homology to the corresponding proteins of species. Decreased expression of PDCD5 has been found in many human tumors, including breast, gastric cancer, astrocytic glioma, chronic myelogenous leukemia and hepatocellular carcinoma. In recent years, increased number of studies have shown the functions and mechanisms of PDCD5 protein in cancer cells, such as paraptosis, cell cycle and immunoregulation. In the present review, we provide a comprehensive review on the role of PDCD5 in cancer tissues and cells. This review summarizes the recent studies of the roles of PDCD5 in inflammation and cancer. We mainly focus on discoveries related to molecular mechanisms of PDCD5 protein. We also discuss some discrepancies between the current studies. Overall, the current available data will open new perspectives for a better understanding of PDCD5 in cancer.
引用
收藏
页码：1801 / 1806
页数：6
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