Anti-inflammatory and mycobacterial activity of leaf extracts of Coleonema album

被引：12
|
作者：
Eldeen, I. M. S. [1 ]
Van Staden, J. [1 ]
机构：
[1] Univ KwaZulu Natal Pietermaritzburg, Sch Biol & Conservat Sci, Res Ctr Plant Growth & Dev, ZA-3209 Scottsville, South Africa
来源：
SOUTH AFRICAN JOURNAL OF BOTANY | 2008年 / 74卷 / 02期
基金：
新加坡国家研究基金会;
关键词：
anti-inflammatory; antimycobacterial; Coleonema album; Rutaceae;
D O I：
10.1016/j.sajb.2007.11.008
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Acetone and ethanolic leaf extracts of Coleonema album were screened for anti-inflammatory and antimycobacterial activity using the cyclooxygenase (COX-1 and COX-2) and broth micro-dilution assays against Mycobacterium aurum A+ respectively. In the cyclooxygenase assays, all extracts showed preferential activity against COX-2 with an IC50 value of 40 mu g/ml for the acetone extract. The same extract had an IC50 value of 225 mu g/ml against COX-1 with a COX-2/COX-1 selectivity ratio of 0.17. In the antimycobacterial test all extracts showed moderate activity against M. aurum with an MIC value of 3.1 mg/ml. The results suggest more in depth investigations into the anti-inflammatory compounds present in C. album. (C) 2007 SAAB. Published by Elsevier B.V All rights reserved.
引用
收藏
页码：345 / 347
页数：3
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