Anti-inflammatory and mycobacterial activity of leaf extracts of Coleonema album

被引：13

作者：

Eldeen, I. M. S. ^{[1
]}

Van Staden, J. ^{[1
]}

机构：

[1] Univ KwaZulu Natal Pietermaritzburg, Sch Biol & Conservat Sci, Res Ctr Plant Growth & Dev, ZA-3209 Scottsville, South Africa

来源：

SOUTH AFRICAN JOURNAL OF BOTANY | 2008年 / 74卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

anti-inflammatory; antimycobacterial; Coleonema album; Rutaceae;

D O I：

10.1016/j.sajb.2007.11.008

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Acetone and ethanolic leaf extracts of Coleonema album were screened for anti-inflammatory and antimycobacterial activity using the cyclooxygenase (COX-1 and COX-2) and broth micro-dilution assays against Mycobacterium aurum A+ respectively. In the cyclooxygenase assays, all extracts showed preferential activity against COX-2 with an IC50 value of 40 mu g/ml for the acetone extract. The same extract had an IC50 value of 225 mu g/ml against COX-1 with a COX-2/COX-1 selectivity ratio of 0.17. In the antimycobacterial test all extracts showed moderate activity against M. aurum with an MIC value of 3.1 mg/ml. The results suggest more in depth investigations into the anti-inflammatory compounds present in C. album. (C) 2007 SAAB. Published by Elsevier B.V All rights reserved.

引用

页码：345 / 347

页数：3

共 14 条

[1] Prenylated phenylpropenes from Coleonema pulchellum with antimicrobial activity [J].