Aripiprazole treatment for patients with schizophrenia: from acute treatment to maintenance treatment

被引:0
作者
Park, Min-Hyeon [2 ]
Han, Changsu [3 ]
Pae, Chi-Un [1 ,4 ]
Lee, Soo-Jung [1 ]
Patkar, Ashwin A. [4 ]
Masand, Praksh S. [4 ]
Fleischhacker, Wolfgang W. [5 ]
机构
[1] Catholic Univ Korea, Dept Psychiat, Bucheon St Marys Hosp, Coll Med, Puchon, Kyonggi Do, South Korea
[2] Seoul Natl Univ, Coll Med, Dept Neuropsychiat, Div Child & Adolescent Psychiat, Seoul, South Korea
[3] Korea Univ, Dept Psychiat, Coll Med, Seoul, South Korea
[4] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC USA
[5] Med Univ Innsbruck, Dept Psychiat & Psychotherapy, Innsbruck, Austria
关键词
acute treatment; aripiprazole; maintenance treatment; schizophrenia; ATYPICAL ANTIPSYCHOTIC-DRUG; DOUBLE-BLIND; ACUTE AGITATION; INTRAMUSCULAR ARIPIPRAZOLE; SCHIZOAFFECTIVE DISORDER; PARTIAL AGONIST; SHORT-TERM; OPEN-LABEL; PLACEBO; OLANZAPINE;
D O I
10.1586/ERN.11.151
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The most current treatment guidelines for schizophrenia recommend more than 1 year of maintenance therapy after the first psychotic episode, and more than 5 years of maintenance therapy after multiple psychotic episodes. Approximately two-thirds of such patients are known to relapse within 1 year and almost 90% of such patients may recur within 2 years. To maintain adequate consistent treatment, balancing the efficacy and safety/tolerability should be one of the most important clinical issues. In this respect, aripiprazole appears to be a good treatment option owing to its comparable efficacy, favorable safety and tolerability profile, including low incidence of parkinsonian symptoms, lack of prolactin elevation, decreased adrenergic and anticholinergic side effects, less weight gain and low incidence of metabolic syndrome. Hence this article aims to summarize the currently available clinical trial data of aripiprazole published from a number of large-scale randomized controlled studies, including a newer formulation of intramuscular injection as well as a once-monthly intramuscular depot formulation, to update knowledge of treatment options in patients with schizophrenia.
引用
收藏
页码:1541 / 1552
页数:12
相关论文
共 50 条
[41]   Clinical issues associated with maintenance treatment of patients with schizophrenia [J].
Guthrie, SK .
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY, 2002, 59 :S19-S24
[42]   Pharmacological treatment algorithms for the acute phase, agitation, and maintenance phase of first-episode schizophrenia: Japanese Society of Clinical Neuropsychopharmacology treatment algorithms [J].
Takeuchi, Hiroyoshi ;
Takekita, Yoshiteru ;
Hori, Hikaru ;
Oya, Kazuto ;
Miura, Itaru ;
Hashimoto, Naoki ;
Yasui-Furukori, Norio .
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, 2021, 36 (06)
[43]   Use of Aripiprazole in treatment resistant schizophrenia [J].
Hughes, D. ;
Morcos, M. .
JOURNAL OF PSYCHOPHARMACOLOGY, 2008, 22 (08) :927-928
[44]   Aripiprazole in the treatment of Huntington's disease: a case series [J].
Ciammola, Andrea ;
Sassone, Jenny ;
Colciago, Clarissa ;
Mencacci, Niccolo E. ;
Poletti, Barbara ;
Ciarmiello, Andrea ;
Squitieri, Ferdinando ;
Silani, Vincenzo .
NEUROPSYCHIATRIC DISEASE AND TREATMENT, 2009, 5 :1-4
[45]   Association of Aripiprazole With Reduced Hippocampal Atrophy During Maintenance Treatment of First-Episode Schizophrenia [J].
Wang, John ;
Hart, Kamber L. ;
Qi, Wei ;
Ardekani, Babak A. ;
Li, Chenxiang ;
Marx, Julia ;
Freudenreich, Oliver ;
Cather, Corinne ;
Holt, Daphne ;
Bello, Iruma ;
Diminich, Erica D. ;
Tang, Yingying ;
Worthington, Michelle ;
Zeng, Botao ;
Wu, Renrong ;
Fan, Xiaoduo ;
Zhao, Jingping ;
Wang, Jijun ;
Goff, Donald C. .
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2021, 41 (03) :244-249
[46]   Acanthosis Nigricans During Treatment With Aripiprazole [J].
Manu, Peter ;
Al-Dhaher, Zainab ;
Dargani, Navin ;
Correll, Christoph U. .
AMERICAN JOURNAL OF THERAPEUTICS, 2014, 21 (03) :E90-E93
[47]   Aripiprazole in the treatment of Alzheimer's disease [J].
De Deyn, Peter Paul ;
Drenth, Annemieke F. J. ;
Kremer, Berry P. ;
Voshaar, Richard C. Oude ;
Van Dam, Debby .
EXPERT OPINION ON PHARMACOTHERAPY, 2013, 14 (04) :459-474
[48]   Treatment of refractory catatonic schizophrenia with low dose aripiprazole [J].
Tsuyoshi Sasaki ;
Tasuku Hashimoto ;
Tomihisa Niitsu ;
Nobuhisa Kanahara ;
Masaomi Iyo .
Annals of General Psychiatry, 11
[49]   Mania Associated with Aripiprazole Treatment in Schizophrenia: a Case Report [J].
Koroglu, Ayse ;
Yeloglu, Cagdas Hunkar ;
Celik, Fatmagul Helvaci ;
Hocaoglu, Cicek ;
Bahceci, Bulent .
DUSUNEN ADAM-JOURNAL OF PSYCHIATRY AND NEUROLOGICAL SCIENCES, 2014, 27 (04) :356-358
[50]   Aripiprazole for the Maintenance Treatment of Bipolar I Disorder: A Review [J].
McIntyre, Roger S. .
CLINICAL THERAPEUTICS, 2010, 32 :S32-S38