Tumor Promoting Aspects of Senescence in Cancer Progression

被引：1

作者：

Yang, Qing ^{[1
]}

Xie, Yingqiu ^{[1
]}

Miao, Lixia ^{[2
]}

机构：

[1] Nazarbayev Univ, Sch Sci & Technol, Dept Biol, 53 Kabanbay Batyr Ave, Astana 010000, Kazakhstan

[2] Wuhan Univ, Coll Basic Med, Wuhan, Peoples R China

来源：

CANCER INVESTIGATION | 2016年 / 34卷 / 09期

关键词：

Senescence; cancer; EPITHELIAL-MESENCHYMAL TRANSITION; SUPPRESSES PROSTATE-CANCER; CELLULAR SENESCENCE; CELLS; METASTASIS; PATHWAYS; PTEN; TUMORIGENESIS; GROWTH; ARF;

D O I：

10.1080/07357907.2016.1227443

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancers induced by gene mutation, deletion, and genome instability might be related to aging. With similar pathways of aging but distinct functions, senescence at the cellular level is an irreversible arrest of cell cycle. Senescence has long been believed as a barrier to restrict tumor expansion. However, more and more evidence has been shown that senescence inducers regulate epithelial-mesenchymal transition, stem cell self-renewal, inflammatory response, crosstalk with the oncogenic bypass signaling, and conversion of oncogene to tumor suppressor. Here we will discuss the most recent findings of the oncogenic aspects of senescence which crosstalk with multiple pathways in cancer progression.

引用

页码：452 / 458

页数：7

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