An ascidian homologue of the gonadotropin-releasing hormone receptor is a retinoic acid target gene

被引：3
|
作者：
Kobayashi, Y
Ohashi, M
Kawamura, K
Yubisui, T
Fujiwara, S [1 ]
机构：
[1] Kochi Univ, Fac Sci, Lab Cellular & Mol Biotechnol, Kochi 7808520, Japan
[2] Okayama Univ Sci, Fac Sci, Dept Biochem, Okayama 7000005, Japan
来源：
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 2005年 / 141卷 / 03期
基金：
日本学术振兴会;
关键词：
ascidian; Polyandrocarpa; asexual reproduction; budding; retinoic acid; transdifferentiation; gonadotropin-releasing hormone receptor; G protein-coupled receptor;
D O I：
10.1016/j.cbpc.2005.03.011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transdifferentiation of the multipotent atrial epithelium is a key event during budding of the ascidian Polyandrocarpa misakiensis. The transdifferentiation is induced by mesenchyme cells that were stimulated by retinoic acid. The fluorescent differential display identified a few cDNA fragments for retinoic acid-inducible genes. One of the cDNA clones, named Pin-GnRHR, encoded a seven-pass transmembrane receptor similar to gonadotropin-releasing hormone receptors. Putative amino acid sequence showed high similarity to Ciona intestinalis GnRHRs and formed a cluster with other GnRHR proteins in a phylogenetic tree. The level of expression of the Pm-GnRHR mRNA increased during the early stage of bud development, suggesting that the Pm-GnRHR function is involved in some aspects of bud development. (c) 2005 Elsevier Inc. All rights reserved.
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页码：274 / 280
页数：7
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