A whole-genome radiation hybrid map of the dog genome

被引：120

作者：

Priat, C ^{[1
]}

Hitte, C ^{[1
]}

Vignaux, F ^{[1
]}

Renier, C ^{[1
]}

Jiang, ZH ^{[1
]}

Jouquand, S ^{[1
]}

Chéron, A ^{[1
]}

André, C ^{[1
]}

Galibert, F ^{[1
]}

机构：

[1] Fac Med, UPR 41 CNRS Recombinaisons Genet, F-35043 Rennes, France

来源：

GENOMICS | 1998年 / 54卷 / 03期

关键词：

D O I：

10.1006/geno.1998.5602

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A whole genome radiation hybrid (RH) map of the canine genome was constructed by typing 400 markers, including 218 genes and 182 microsatellites, on a panel of 126 radiation hybrid cell lines. Fifty-seven RH groups have been determined with lod scores greater than 6, and 180 framework landmarks were ordered with odds greater than 1000:1. Average spacing between adjacent markers is 23 cR(5000), an estimated physical distance of 3.8 Mb. Fourteen groups have been assigned to 9 of the canine chromosomes, and a comparison of RH and genetic groups allowed the successful bridging of both types of data on one map composed of 31 RH and 13 syntenic RH groups. Comparison of canine, human, mouse, and pig maps underlined regions of conserved synteny. This integrated map, covering an estimated 80% of the dog genome, should prove a powerful tool for localizing and identifiying genes implicated in pathological and phenotypical traits. (C) 1998 Academic Press.

引用

页码：361 / 378

页数：18

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