From role of gut microbiota to microbial-based therapies in type 2-diabetes

被引：62
|
作者：
Leylabadlo, Hamed Ebrahimzadeh [1 ,2 ,3 ]
Sanaie, Sarvin [2 ,4 ]
Heravi, Fatemah Sadeghpour [5 ]
Ahmadian, Zainab [6 ]
Ghotaslou, Reza [1 ,3 ]
机构：
[1] Tabriz Univ Med Sci, Liver & Gastrointestinal Dis Res Ctr, Tabriz, Iran
[2] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran
[3] Tabriz Univ Med Sci, Fac Med, Dept Bacteriol & Virol, Tabriz, Iran
[4] Tabriz Univ Med Sci, Aging Res Inst, Tabriz, Iran
[5] Macquarie Univ, Fac Med & Hlth Sci, Surg Infect Res Grp, Sydney, NSW 2019, Australia
[6] Zanjan Univ Med Sci, Sch Pharm, Dept Pharmaceut, Zanjan 45139561821, Iran
来源：
INFECTION GENETICS AND EVOLUTION | 2020年 / 81卷
关键词：
Microbiota; Microbiome; Prebiotics; Probiotics; Type; 2; diabetes; TRIMETHYLAMINE-N-OXIDE; GLUCAGON-LIKE PEPTIDE-1; IMPAIRED GLUCOSE-TOLERANCE; INULIN-TYPE FRUCTANS; CHAIN AMINO-ACIDS; DIABETES-MELLITUS; LIPID PROFILE; DOUBLE-BLIND; INTESTINAL MICROBIOTA; METABOLIC ENDOTOXEMIA;
D O I：
10.1016/j.meegid.2020.104268
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The incidence of type 2 diabetes mellitus (T2DM) has increased dramatically at an alarming level around the world.T2DM is associated with changeable risk factors in lifestyle as well as genetic and family associated risk factors. More importantly, imbalanced or impaired gut microbial distribution (dysbiosis) has been reported as a contributing risk factor in insulin resistance progression in T2DM. Dysbiosis may restructure the metabolic and functional pathways in the intestine which are involved in the development of T2DM. However, several studies have indicated the constructive and helpful effect of prebiotics, probiotics, and fecal microbiota transplantation (FMT) on the improvement of gut microbiota (GM) and accordingly host metabolism. In this review, the association between GM and T2DM have been evaluated and the role of prebiotics, probiotics and FMT, as potential therapeutic approaches have been discussed. Relevant studies were obtained randomly from online databases such as PubMed/Medline and ISI Web of Science.
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收藏
页数：12
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