68Ga-FAPI PET/CT Improves Therapeutic Strategy by Detecting a Second Primary Malignancy in a Patient With Rectal Cancer

被引：18

作者：

Chen, Haojun ^{[1
,2
]}

Zhao, Liang

Ruan, Dan ^{[1
,2
]}

Sun, Long ^{[1
,2
]}

Lin, Qin ^{[3
]}

机构：

[1] Xiamen Univ, Dept Nucl Med, Xiamen, Peoples R China

[2] Xiamen Univ, Minnan PET Ctr, Xiamen, Peoples R China

[3] Fujian Med Univ, Teaching Hosp, Xiamen Univ, Dept Radiat Oncol,Affiliated Hosp 1, Xiamen, Peoples R China

来源：

CLINICAL NUCLEAR MEDICINE | 2020年 / 45卷 / 06期

关键词：

F-18-FDG; Ga-68-FAPI; double primary malignancies; PET/CT; LUNG; CT;

D O I：

10.1097/RLU.0000000000003000

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A 71-year-old man with pathologically confirmed rectal cancer underwent F-18-FDG PET/CT before radical operation, which showed multiple nodules with low uptake in bilateral pleura and 1 solitary pulmonary nodule with slight uptake in left lung. The subpleural nodule was diagnosed as benign lesion through the biopsy. Ga-68-labeled fibroblast-activation-protein inhibitor PET/CT was performed for further evaluation, which showed low uptake in bilateral subpleural nodules but focally increased uptake in the nodule of left lung. This nodule was found to be a primary lung adenocarcinoma by the CT-guided biopsy. A diagnosis of rectum and lung double primary malignancies was finally made.

引用

页码：468 / 470

页数：3

共 8 条

[1] Alveolar Sarcoidosis With Intense FDG Uptake, Mimicking Multi-focal Pneumonia and Infiltrative Lung Malignancy [J].

Ansari-Gilani, Kianoush ;

Yang, Michael ;

Ramaiya, Nikhil H. .

CLINICAL NUCLEAR MEDICINE, 2019, 44 (08) :653-654

[2] Recommendations for Measuring Pulmonary Nodules at CT: A Statement from the Fleischner Society [J].

Bankier, Alexander A. ;

MacMahon, Heber ;

Goo, Jin Mo ;

Rubin, Geoffrey D. ;

Schaefer-Prokop, Cornelia M. ;

Naidich, David P. .

RADIOLOGY, 2017, 285 (02) :584-600

[3] Rationale Behind Targeting Fibroblast Activation Protein-Expressing Carcinoma-Associated Fibroblasts as a Novel Chemotherapeutic Strategy [J].

Brennen, W. Nathaniel ;

Isaacs, John T. ;

Denmeade, Samuel R. .

MOLECULAR CANCER THERAPEUTICS, 2012, 11 (02) :257-266

[4] Relationship between nodule count and lung cancer probability in baseline CT lung cancer screening: The NELSON study [J].

Heuvelmans, Marjolein A. ;

Walter, Joan E. ;

Peters, Robin B. ;

de Bock, Geertruida H. ;

Yousaf-Khan, Uraujh ;

van der Aalst, Carlijn M. ;

Groen, Harry J. M. ;

Nackaerts, Kristiaan ;

van Ooijen, Peter M. A. ;

de Koning, Harry J. ;

Oudkerk, Matthijs ;

Vliegenthart, Rozemarijn .

LUNG CANCER, 2017, 113 :45-50

[5] 68Ga-PSMA Avid Primary Adenocarcinoma of the Lung With Complementary Low 18F-FDG Uptake [J].

Jochumsen, Mads Ryo ;

Gormsen, Lars Christian ;

Nielsen, Gitte Lund .

CLINICAL NUCLEAR MEDICINE, 2018, 43 (02) :117-119

[6] 68Ga-FAPI PET/CT: Tracer Uptake in 28 Different Kinds of Cancer [J].

Kratochwil, Clemens ;

Flechsig, Paul ;

Lindner, Thomas ;

Abderrahim, Labidi ;

Altmann, Annette ;

Mier, Walter ;

Adeberg, Sebastian ;

Rathke, Hendrik ;

Roehrich, Manuel ;

Winter, Hauke ;

Plinkert, Peter K. ;

Marme, Frederik ;

Lang, Matthias ;

Kauczor, Hans-Ulrich ;

Jaeger, Dirk ;

Debus, Juergen ;

Haberkorn, Uwe ;

Giesel, Frederik L. .

JOURNAL OF NUCLEAR MEDICINE, 2019, 60 (06) :801-805

[7] A Tumor-Imaging Method Targeting Cancer-Associated Fibroblasts [J].

Loktev, Anastasia ;

Lindner, Thomas ;

Mier, Walter ;

Debus, Juergen ;

Altmann, Annette ;

Jaeger, Dirk ;

Giesel, Frederik ;

Kratochwil, Clemens ;

Barthe, Philippe ;

Roumestand, Christian ;

Haberkorn, Uwe .

JOURNAL OF NUCLEAR MEDICINE, 2018, 59 (09) :1423-1429

[8] Update in the Evaluation of the Solitary Pulmonary Nodule [J].

Truong, Mylene T. ;

Ko, Jane P. ;

Rossi, Santiago E. ;

Rossi, Ignacio ;

Viswanathan, Chitra ;

Bruzzi, John F. ;

Marom, Edith M. ;

Erasmus, Jeremy J. .

RADIOGRAPHICS, 2014, 34 (06) :1658-1679

← 1 →