Review on Autoimmune Reactions in Female Infertility: Antibodies to Follicle Stimulating Hormone

被引：55

作者：

Haller-Kikkatalo, Kadri ^{[1
,2
,3
]}

Salumets, Andres ^{[2
,3
]}

Uibo, Raivo ^{[1
,3
]}

机构：

[1] Univ Tartu, Inst Gen & Mol Pathol, Dept Immunol, Biomedicum, EE-50411 Tartu, Estonia

[2] Univ Tartu, Dept Obstet & Gynecol, EE-51014 Tartu, Estonia

[3] Competence Ctr Reprod Med & Biol, EE-50410 Tartu, Estonia

来源：

CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2012年

关键词：

IN-VITRO FERTILIZATION; PREMATURE OVARIAN FAILURE; GROWTH-FACTOR-BETA; UNEXPLAINED INFERTILITY; REPRODUCTIVE FAILURE; SEMINAL PLASMA; ANTIPHOSPHOLIPID ANTIBODIES; ANTIOVARIAN ANTIBODIES; POLYGLANDULAR SYNDROME; IMPLANTATION FAILURE;

D O I：

10.1155/2012/762541

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Female fertility can be affected by diseases or dysfunctions of reproductive tract, neuroendocrine system, and immune system. Reproductive autoimmune failure can be associated with overall activation of immune system or with immune system reactions specifically directed against ovarian antigens. Majority of the antiovarian autoantibodies are directed against beta-subunit of follicle stimulating hormone (anti-FSH). This paper summarizes a current clinical classification of female infertility in the context of general activation of autoimmunity and antiovarian autoimmunity by describing serum anti-FSH. The presence of naturally occurring anti-FSH in healthy women will be discussed. In addition, the putative impairment of ovarian folliculogenesis in case of increased production of those antibodies in infertile women will be characterized.

引用

页数：15

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