Molecular cloning and characterization of a mono(ADP-ribosyl)transferase from human testis

被引：0
|
作者：
Levy, I [1 ]
Pawlak, A [1 ]
Mattei, MG [1 ]
Guellaen, G [1 ]
机构：
[1] HOP ENFANTS LA TIMONE, INSERM, U406, F-13385 MARSEILLE, FRANCE
来源：
ADP-RIBOSYLATION IN ANIMAL TISSUES: STRUCTURE, FUNCTION, AND BIOLOGY OF MONO (ADP-RIBOSYL) TRANSFERASES AND RELATED ENZYMES | 1997年 / 419卷
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中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A human homologue of the rodent T cell mono(ADP-ribosyl)transferase RT6 mRNA was identified by a systematic partial sequencing of human testis transcripts. This messenger encodes for a precursor protein of 367 aa (MW: 41.5 kDa) which exhibits a peptide signal, consensus domains for mono(ADP-ribosyl)transferase and a C terminal part which contains three repeated motives (GEKNQKLEDH) and a region characteristic of glycophosphatidyl inositol anchored proteins. This mRNA is transcribed from a gene localized in 4q13-q21. Surprisingly, it is not expressed in human white blood cells but it exhibits a very specific testis expression in which it is likely to correspond to a new ADP-ribosyl transferase.
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页码：121 / 128
页数：8
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