Synthesis of 1-Benzyl-4-[2-(5-phenyl-1,3,4-thiadiazole-2-yl)aminoethyl]piperidine as Potential Alzheimer's Disease Modifying Agent

被引：0
作者：
Sarkandi, Diba Nabardi [2 ]
Firoozpour, Loghman [3 ]
Asadipour, Ali [1 ]
Sheibani, Vahid [1 ]
Asli, Mahsa Alizadeh Monavar [2 ]
Davood, Asghar [2 ]
Shafiee, Abbas [4 ,5 ]
Foroumadi, Alireza [1 ,4 ,5 ]
机构：
[1] Kerman Univ Med Sci, Kerman Neurosci Res Ctr, Kerman, Iran
[2] Islamic Azad Univ, Pharmaceut Sci Branch, Dept Med Chem, Tehran, Iran
[3] Univ Tehran Med Sci, Drug Design & Dev Res Ctr, Tehran, Iran
[4] Univ Tehran Med Sci, Fac Pharm, Dept Med Chem, Tehran, Iran
[5] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, Tehran, Iran
来源：
ASIAN JOURNAL OF CHEMISTRY | 2011年 / 23卷 / 06期
关键词：
Synthesis; 1,3,4-Thiadiazole; Piperidine; Alzheimer's disease; ACETYLCHOLINESTERASE INHIBITORS; CHOLINESTERASE-INHIBITORS; DERIVATIVES; DONEPEZIL; DESIGN;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A number of pharmacological agents are available for clinical use in the treatment of alzheimer's disease. The cognitive impairment associated with alzheimer's disease is characterized by reduced levels of acetylcholine in CNS. Acetyl cholinesterase inhibitors increase the level of acetyl choline at the synapses by blocking the breakdown of the neurotransmitter. The aim of this study is the synthesis of 1-benzyl-4-[2-(5-phenyl-1,3,4-thiadiazole-2-yl)aminoethyl]piperidine, as potential acetyl cholinesterase inhibitor, from the reaction of 2-chloro-5-phenyl-1,3,4-thiadiazole and 1-benzyl(piperidin-4-yl)ethylamine. The structure of obtained compound was identified by its (1)H NMR, mass and IR spectra.
引用
收藏
页码：2503 / 2505
页数：3
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