The renin-angiotensin system genetic polymorphisms and rheumatic mitral valve disease

被引:0
作者
Ozisik, K
Emir, M
Ulus, AT
Kaplan, S
Misirlioglu, M
Tuncer, AS
Katircioglu, SF
机构
[1] Ankara Numune Educ & Res Hosp, Dept Cardiovasc Surg, Ankara, Turkey
[2] TYIH, Dept Cardiovasc Surg, Ankara, Turkey
[3] Metis Biotechnol Ltd, Ankara, Turkey
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中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and aim of the study: Angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism, angiotensinogen (AGT) gene polymorphism and angiotensin II type 1 receptor (AT1R) polymorphism in relation to rheumatic mitral valve disease were examined in a case-control study to investigate possible relationships between these gene polymorphisms and rheumatic mitral valve disease in patients undergoing mitral valve replacement (MVR). Methods: A total of 50 patients with rheumatic mitral valve disease and undergoing MVR was compared with 50 normal, and age- and sex-matched control subjects. ACE VD, AGT gene M235T and AT1R-adenine/cytosine 1166 (A1166C) genotype polymorphisms were identified by polymerase chain reaction (PCR)-based restriction analysis.. Results: ACE I/D polymorphism differed significantly between the groups. The control group mostly represented the heterozygote ID allele (74%), while the MVR group showed frequencies of 60% for the homozygote DD and II alleles. MM homozygote-frequency was significantly greater in controls, but TT homozygote frequency was significantly greater in the MVR group. AT1R-A1166C genotype polymorphism also differed significantly between groups; the MVR group had 73.7% of the AC heterozygote allele, while controls had 64.4% of the AA and 66.7% of the CC homozygote alleles. Conclusion: These results provided evidence of. an association between ACE I/D polymorphism, M235T polymorphism and AT1R-A1166C genotype,polymorphism and rheumatic mitral valve disease.
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页码:33 / 37
页数:5
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