Steroidogenesis enzyme inhibitors in Cushing's syndrome

被引：65

作者：

Daniel, Eleni ^{[1
]}

Newell-Price, John D. C. ^{[2
]}

机构：

[1] Univ Sheffield, Dept Human Metab, Sheffield S10 2RX, S Yorkshire, England

[2] Univ Sheffield, Dept Endocrinol, Acad Unit Endocrinol, Sheffield S10 2RX, S Yorkshire, England

来源：

EUROPEAN JOURNAL OF ENDOCRINOLOGY | 2015年 / 172卷 / 06期

关键词：

ALDOSTERONE SYNTHASE INHIBITION; MULTIPLE TRAUMA PATIENTS; CRITICALLY-ILL PATIENTS; IDEAL INDUCTION AGENT; LONG-TERM MANAGEMENT; LOW-DOSE ETOMIDATE; OF-THE-LITERATURE; ADRENOCORTICAL CARCINOMA; ADRENAL STEROIDOGENESIS; DOUBLE-BLIND;

D O I：

10.1530/EJE-14-1014

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Steroidogenesis enzyme inhibitors are the mainstay of medical therapy in Cushing's syndrome (CS). Ketoconazole (KTZ) and metyrapone are the most commonly used agents. Although there is considerable experience of their use in individual specialist centres, these drugs have not been rigorously tested in prospective clinical trials. Clinicians face uncertainties and concerns with respect to the safety profile of these agents, and best means to monitor effect. We review steroidogenesis inhibitors in the management of CS, including older agents (KTZ, metyrapone, etomidate and mitotane) and those currently under development (LCI699, non-racemic KTZ), and offer a practical approach for their use in clinical practice.

引用

页码：R263 / R280

页数：18

共 162 条

[1]

Absalom A, 1999, ANAESTHESIA, V54, P861

[2] Pregnancy-induced Cushing's syndrome in recurrent pregnancies: Case report and literature review [J].

Achong, Naomi ;

D'Emden, Michael ;

Fagermo, Narelle ;

Mortimer, Robin .

AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, 2012, 52 (01) :96-100

[3]

Agency EM, 2013, SUSPENSION OF MARKET

[4] Assessment of serum-free cortisol levels in patients with adrenocortical carcinoma treated with mitotane: a pilot study [J].

Alexandraki, Krystallenia I. ;

Kaltsas, Gregory A. ;

le Roux, Carel W. ;

Fassnacht, Martin ;

Ajodha, Sharon ;

Christ-Crain, Mirjam ;

Akker, Scott A. ;

Drake, William M. ;

Edwards, Ray ;

Allolio, Bruno ;

Grossman, Ashley B. .

CLINICAL ENDOCRINOLOGY, 2010, 72 (03) :305-311

[5] ADRENOCORTICAL SUPPRESSION BY A SINGLE INDUCTION DOSE OF ETOMIDATE [J].

ALLOLIO, B ;

STUTTMANN, R ;

LEONHARD, U ;

FISCHER, H ;

WINKELMANN, W .

KLINISCHE WOCHENSCHRIFT, 1984, 62 (21) :1014-1017

[6] NONHYPNOTIC LOW-DOSE ETOMIDATE FOR RAPID CORRECTION OF HYPERCORTISOLEMIA IN CUSHINGS-SYNDROME [J].

ALLOLIO, B ;

SCHULTE, HM ;

KAULEN, D ;

REINCKE, M ;

JAURSCHHANCKE, C ;

WINKELMANN, W .

KLINISCHE WOCHENSCHRIFT, 1988, 66 (08) :361-364

[7] EFFECT OF A SINGLE BOLUS OF ETOMIDATE UPON 8 MAJOR CORTICOSTEROID HORMONES AND PLASMA ACTH [J].

ALLOLIO, B ;

DORR, H ;

STUTTMANN, R ;

KNORR, D ;

ENGELHARDT, D ;

WINKELMANN, W .

CLINICAL ENDOCRINOLOGY, 1985, 22 (03) :281-286

[8] SUCCESSFUL TREATMENT WITH KETOCONAZOLE OF CUSHINGS-SYNDROME IN PREGNANCY [J].

AMADO, JA ;

PESQUERA, C ;

GONZALEZ, EM ;

OTERO, M ;

FREIJANES, J ;

ALVAREZ, A .

POSTGRADUATE MEDICAL JOURNAL, 1990, 66 (773) :221-223

[9] Aldosterone Synthase Inhibition With LCI699 A Proof-of-Concept Study in Patients With Primary Aldosteronism [J].

Amar, Laurence ;

Azizi, Michel ;

Menard, Joel ;

Peyrard, Severine ;

Watson, Catherine ;

Plouin, Pierre-Francois .

HYPERTENSION, 2010, 56 (05) :831-+

[10] The Effects of Aldosterone Synthase Inhibition on Aldosterone and Cortisol in Patients With Hypertension: A Phase II, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study [J].

Andersen, Karl ;

Hartman, Daniel ;

Peppard, Thomas ;

Hermann, David ;

Van Ess, Peter ;

Lefkowitz, Martin ;

Trapani, Angelo .

JOURNAL OF CLINICAL HYPERTENSION, 2012, 14 (09) :580-587

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