Improvement of the Van Leusen reaction in the presence of β-cyclodextrin: a green and efficient synthesis of oxazoles in water

被引：7

作者：

Rahimzadeh, Golnaz ^{[1
]}

Kianmehr, Ebrahim ^{[1
]}

Mahdavi, Mohammad ^{[2
]}

机构：

[1] Univ Tehran, Sch Chem, Coll Sci, Tehran, Iran

[2] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, Tehran, Iran

来源：

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES | 2017年 / 72卷 / 12期

基金：

美国国家科学基金会;

关键词：

aldehydes; beta-cyclodextrin; oxazoles; tosylmethyl isocyanide (TosMIC); Van Leusen reaction; CHEMISTRY; ALPHA; CYCLOADDITION; CONDENSATION; DERIVATIVES; ISOCYANIDE; SOLVENTS;

D O I：

10.1515/znb-2017-0005

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An efficient approach for the synthesis of oxazoles through the Van Leusen reaction in the presence of beta-cyclodextrin is described. In aqueous medium using beta-cyclodextrin as a supramolecular catalyst, tosylmethyl isocyanide was deprotonated by triethylamine and subsequently underwent an addition/cyclization reaction with aldehydes to produce corresponding oxazoles in excellent yields. This protocol improves the Van Leusen reaction with the use of catalytic amounts of base at low temperature in green media.

引用

收藏

页码：923 / 926

页数：4

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