Prognostic impact of micromegakaryocytes in primary myelodysplastic syndromes

被引：1

作者：

Saumell, Silvia ^{[1
]}

Fernandez-Serrano, Miranda ^{[2
,3
]}

Mesa, Alba ^{[1
]}

Lopez-Cadenas, Felix ^{[4
]}

Arenillas, Leonor ^{[5
]}

Alfonso, Ana ^{[6
]}

Julia Montoro, Maria ^{[1
]}

Molero, Antonieta ^{[1
]}

Leoz, Pilar ^{[4
]}

Riego, Victoria ^{[6
]}

Gallur, Laura ^{[1
]}

Salamero, Olga ^{[1
]}

Navarrete, Mayda ^{[1
]}

Tazon-Vega, Barbara ^{[1
]}

Ortega, Margarita ^{[1
]}

Reig, Oscar ^{[7
]}

Roue, Gael ^{[1
,3
]}

Calvo, Xavier ^{[5
]}

Prosper, Felipe ^{[6
]}

Diez-Campelo, Maria ^{[4
]}

Valcarcel, David ^{[1
]}

机构：

[1] Univ Hosp Vall dHebron, Vall dHebron Inst Oncol VHIO, Dept Hematol, Expt Hematol Unit, Pssg Vall dHebron 119-129, Barcelona 08035, Spain

[2] Univ Autonoma Barcelona, Dept Biochem & Mol Biol, Barcelona, Spain

[3] Josep Carreras Leukaemia Res Inst, Lymphoma Translat Grp, Barcelona, Spain

[4] Univ Hosp Salamanca, Dept Hematol, Salamanca, Spain

[5] IMIM Hosp Mar, Dept Pathol, Lab Cytol, GRETNHE,Res Inst, Barcelona, Spain

[6] Univ Navarra, Clin Univ Navarra, Pamplona, Spain

[7] Hosp Clin Barcelona, Med Oncol Dept, Translat Genom & Targeted Therapeut Solid Tumors, Barcelona, Spain

来源：

LEUKEMIA & LYMPHOMA | 2022年 / 63卷 / 05期

关键词：

Micromegakaryocytes; myelodysplastic syndromes; prognostic factor; myeloid dysplasia; IPSS-R; MDS; ACUTE MYELOID-LEUKEMIA; SCORING SYSTEM; CLASSIFICATION; DYSPLASIA; MEGAKARYOCYTES; CRITERIA;

D O I：

10.1080/10428194.2021.2018581

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Micromegakaryocytes (microMKs) are considered a myelodysplastic feature of myeloid neoplasms in adults, with an adverse prognosis connotation. However, this notion in MDS has not been well proved. In our cohort of 287 MDS, patients with microMKs showed lower overall survival (OS) (HR, 2.12; 95% CI, 1.47-3.06; p = 0.000036) and higher risk of acute myeloid leukemia (AML) evolution (HR, 4.8; 95% CI, 2.9-11.01; p = 0.00021). Results were validated with an independent cohort. In multivariate analysis, the presence of microMKs maintained its independent association with OS (HR, 1.54, 95% CI, 1.13-2.1, p = 0.0059) and AML transformation (HR, 2.28, 95% CI, 1.2-4.4, p = 0.014). Moreover, by adding 1 point to the IPSS-R score in patients with microMKs, we improved the IPSS-R accuracy. Interestingly, adding that 1-point, 29% of intermediate IPSS-R risk group patients were upgraded to the high-risk group. In summary, we confirmed that the presence of microMKs implies worse outcomes in MDS and suggested a modification improving IPSS-R.

引用

页码：1227 / 1235

页数：9

共 17 条

[1] Myelodysplastic Syndromes [J].

Cazzola, Mario .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (14) :1358-1374

[2] Validation of WHO classification-based Prognostic Scoring System (WPSS) for myelodysplastic syndromes and comparison with the revised International Prognostic Scoring System (IPSS-R). A study of the International Working Group for Prognosis in Myelodysplasia (IWG-PM) [J].

Della Porta, M. G. ;

Tuechler, H. ;

Malcovati, L. ;

Schanz, J. ;

Sanz, G. ;

Garcia-Manero, G. ;

Sole, F. ;

Bennett, J. M. ;

Bowen, D. ;

Fenaux, P. ;

Dreyfus, F. ;

Kantarjian, H. ;

Kuendgen, A. ;

Levis, A. ;

Cermak, J. ;

Fonatsch, C. ;

Le Beau, M. M. ;

Slovak, M. L. ;

Krieger, O. ;

Luebbert, M. ;

Maciejewski, J. ;

Magalhaes, S. M. M. ;

Miyazaki, Y. ;

Pfeilstoecker, M. ;

Sekeres, M. A. ;

Sperr, W. R. ;

Stauder, R. ;

Tauro, S. ;

Valent, P. ;

Vallespi, T. ;

van de Loosdrecht, A. A. ;

Germing, U. ;

Haase, D. ;

Greenberg, P. L. ;

Cazzola, M. .

LEUKEMIA, 2015, 29 (07) :1502-1513

[3] A systematic classification of megakaryocytic dysplasia and its impact on prognosis for patients with myelodysplastic syndromes [J].

Feng G. ;

Gale R.P. ;

Cui W. ;

Cai W. ;

Huang G. ;

Xu Z. ;

Qin T. ;

Zhang Y. ;

Li B. ;

Fang L. ;

Zhang H. ;

Pan L. ;

Hu N. ;

Qu S. ;

Wang J. ;

Cui Y. ;

Xiao Z. .

Experimental Hematology & Oncology, 5 (1)

[4] The importance of adequate recognition of normal and dysplastic myelopoiesis for the diagnosis of myelodysplastic syndromes [J].

Florensa, Lourdes ;

Arenillas, Leonor ;

Calvo, Xavier ;

Perez-Vila, Encarnacion ;

Montesdeoca, Sara ;

Ferrer, Ana ;

Woessner, Soledad .

HISTOLOGY AND HISTOPATHOLOGY, 2019, 34 (08) :857-873

[5] Evaluation of dysplasia through detailed cytomorphology in 3156 patients from the Dusseldorf Registry on myelodysplastic syndromes [J].

Germing, Ulrich ;

Strupp, Corinna ;

Giagounidis, Aristoteles ;

Haas, Rainer ;

Gattermann, Norbert ;

Starke, Carsten ;

Aul, Carlo .

LEUKEMIA RESEARCH, 2012, 36 (06) :727-734

[6]

Goasguen Jean E, 2016, Leuk Res, V45, P75, DOI 10.1016/j.leukres.2016.04.009

[7] Revised International Prognostic Scoring System for Myelodysplastic Syndromes [J].

Greenberg, Peter L. ;

Tuechler, Heinz ;

Schanz, Julie ;

Sanz, Guillermo ;

Garcia-Manero, Guillermo ;

Sole, Francesc ;

Bennett, John M. ;

Bowen, David ;

Fenaux, Pierre ;

Dreyfus, Francois ;

Kantarjian, Hagop ;

Kuendgen, Andrea ;

Levis, Alessandro ;

Malcovati, Luca ;

Cazzola, Mario ;

Cermak, Jaroslav ;

Fonatsch, Christa ;

Le Beau, Michelle M. ;

Slovak, Marilyn L. ;

Krieger, Otto ;

Luebbert, Michael ;

Maciejewski, Jaroslaw ;

Magalhaes, Silvia M. M. ;

Miyazaki, Yasushi ;

Pfeilstoecker, Michael ;

Sekeres, Mikkael ;

Sperr, Wolfgang R. ;

Stauder, Reinhard ;

Tauro, Sudhir ;

Valent, Peter ;

Vallespi, Teresa ;

van de Loosdrecht, Arjan A. ;

Germing, Ulrich ;

Haase, Detlef .

BLOOD, 2012, 120 (12) :2454-2465

[8] A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research [J].

Koo, Terry K. ;

Li, Mae Y. .

JOURNAL OF CHIROPRACTIC MEDICINE, 2016, 15 (02) :155-163

[9] DIAGNOSTIC-SIGNIFICANCE OF DETECTING PSEUDO-PELGER-HUET ANOMALIES AND MICRO-MEGAKARYOCYTES IN MYELODYSPLASTIC SYNDROME [J].

KURIYAMA, K ;

TOMONAGA, M ;

MATSUO, T ;

GINNAI, I ;

ICHIMARU, M .

BRITISH JOURNAL OF HAEMATOLOGY, 1986, 63 (04) :665-669

[10] Diagnosis and treatment of primary myelodysplastic syndromes in adults: recommendations from the European LeukemiaNet [J].

Malcovati, Luca ;

Hellstrom-Lindberg, Eva ;

Bowen, David ;

Ades, Lionel ;

Cermak, Jaroslav ;

del Canizo, Consuelo ;

Della Porta, Matteo G. ;

Fenaux, Pierre ;

Gattermann, Norbert ;

Germing, Ulrich ;

Jansen, Joop H. ;

Mittelman, Moshe ;

Mufti, Ghulam ;

Platzbecker, Uwe ;

Sanz, Guillermo F. ;

Selleslag, Dominik ;

Skov-Holm, Mette ;

Stauder, Reinhard ;

Symeonidis, Argiris ;

van de Loosdrecht, Arjan A. ;

de Witte, Theo ;

Cazzola, Mario .

BLOOD, 2013, 122 (17) :2943-2964

← 1 2 →