Research Progress on the Natural Product Aloperine and Its Derivatives

被引：8

作者：

Cheng, Yu ^{[1
]}

Rauf, Abdur ^{[2
]}

Pan, Xiandao ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing 100050, Peoples R China

[2] Univ Swabi, Dept Chem, Anbar, KPK, Pakistan

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2022年 / 22卷 / 05期

关键词：

Aloperine; structure elucidation; total synthesis; antivirus structure-activity relationship; anti-inflammatory effect; anticancer activity; molecular mechanisms; NF-KAPPA-B; SIGNALING PATHWAYS; OXIDATIVE STRESS; HIV-1; ENTRY; QUINOLIZIDINE ALKALOIDS; RAF/MEK/ERK PATHWAY; DEATH PATHWAY; APOPTOSIS; INJURY; VIRUS;

D O I：

10.2174/1389557521666210831155426

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In this review, an effort towards presenting an all-around account of the recent progress on the natural product, aloperine, is made, and the antivirus structure-activity relationship of its derivatives is also summarized comprehensively. In addition, the principal pharmacological effects and corresponding molecular mechanisms of aloperine are discussed. Some new structural modifications of aloperine are also given, which might provide brief guidance for further investigations on the natural product aloperine.

引用

页码：729 / 742

页数：14

共 90 条

[1] Oxidative stress in neurodegeneration: cause or consequence? [J].

Andersen, JK .

NATURE MEDICINE, 2004, 10 (07) :S18-S25

[2] The NF-kappa B and I kappa B proteins: New discoveries and insights [J].

Baldwin, AS .

ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 :649-683

[3] Enzyme assisted enantioselective synthesis of the alkaloid (+)-aloperine [J].

Barilli, A ;

Belinghieri, F ;

Passarella, D ;

Lesma, G ;

Riva, S ;

Silvani, A ;

Danieli, B .

TETRAHEDRON-ASYMMETRY, 2004, 15 (18) :2921-2925

[4] Identification of a Small-Molecule Entry Inhibitor for Filoviruses [J].

Basu, Arnab ;

Li, Bing ;

Mills, Debra M. ;

Panchal, Rekha G. ;

Cardinale, Steven C. ;

Butler, Michelle M. ;

Peet, Norton P. ;

Majgier-Baranowska, Helena ;

Williams, John D. ;

Patel, Ishan ;

Moir, Donald T. ;

Bavari, Sina ;

Ray, Ranjit ;

Farzan, Michael R. ;

Rong, Lijun ;

Bowlin, Terry L. .

JOURNAL OF VIROLOGY, 2011, 85 (07) :3106-3119

[5] Oxidative Stress and Antioxidant Defense [J].

Birben, Esra ;

Sahiner, Umit Murat ;

Sackesen, Cansin ;

Erzurum, Serpil ;

Kalayci, Omer .

WORLD ALLERGY ORGANIZATION JOURNAL, 2012, 5 :9-19

[6] HIV Entry and Envelope Glycoprotein-mediated Fusion [J].

Blumenthal, Robert ;

Durell, Stewart ;

Viard, Mathias .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (49) :40841-40849

[7] New Aloperine-Isoflavone Conjugates [J].

Bondarenko, S. P. ;

Frasinyuk, M. S. ;

Khilya, V. P. .

CHEMISTRY OF NATURAL COMPOUNDS, 2016, 52 (04) :615-619

[8] Total synthesis of (+)-aloperine. Use of a nitrogen-bound silicon tether in an intramolecular Diels-Alder reaction [J].

Brosius, AD ;

Overman, LE ;

Schwink, L .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (04) :700-709

[9] Relative and absolute configuration of aloperine [J].

Brosius, AD ;

Ziller, JW ;

Zhang, QM .

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1997, 53 :1510-1512

[10] Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle [J].

Carvalho, E ;

Kotani, K ;

Peroni, OD ;

Kahn, BB .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2005, 289 (04) :E551-E561

← 1 2 3 4 5 6 7 8 9 →