Long-term sequelae are highly prevalent one year after hospitalization for severe COVID-19

被引:99
作者
Bellan, Mattia [1 ,2 ,4 ]
Baricich, Alessio [1 ,2 ]
Patrucco, Filippo [1 ,2 ]
Zeppegno, Patrizia [1 ,2 ]
Gramaglia, Carla [1 ,2 ]
Balbo, Piero Emilio [2 ]
Carriero, Alessandro [1 ,2 ]
Amico, Chiara Santa [1 ]
Avanzi, Gian Carlo [1 ,2 ]
Barini, Michela [2 ]
Battaglia, Marco [1 ,2 ]
Bor, Simone [1 ,2 ]
Cantaluppi, Vincenzo [1 ,2 ]
Cappellano, Giuseppe [1 ]
Ceruti, Federico [1 ,2 ]
Chiocchetti, Annalisa [1 ]
Clivati, Elisa [2 ]
Giordano, Mara [1 ,2 ]
Cuneo, Daria [1 ,2 ]
Gambaro, Eleonora [1 ,2 ]
Gattoni, Eleonora [2 ]
Loro, Alberto [1 ,2 ]
Manfredi, Marcello [1 ]
Morosini, Umberto [1 ]
Murano, Francesco [1 ,2 ]
Paracchini, Elena [2 ]
Patti, Giuseppe [1 ,2 ]
Pinato, David James [1 ,3 ]
Raineri, Davide [1 ]
Rolla, Roberta [2 ]
Sainaghi, Pier Paolo [1 ,2 ]
Tricca, Stefano [1 ]
Pirisi, Mario [1 ,2 ]
机构
[1] Univ Piemonte Orientale UPO, Novara, Italy
[2] AOU Maggiore Carita, Novara, Italy
[3] Imperial Coll London, Hammersmith Hosp, Dept Surg & Canc, London, England
[4] Univ Piemonte Orientale UPO, Dept Translat Med, Via Solaroli 17, I-28100 Novara, NO, Italy
关键词
EVENT SCALE; WALK TEST; RELIABILITY; PERFORMANCE; MORTALITY; COHORT; IMPACT;
D O I
10.1038/s41598-021-01215-4
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Many coronavirus disease 2019 (Covid-19) survivors show symptoms months after acute illness. The aim of this work is to describe the clinical evolution of Covid-19, one year after discharge. We performed a prospective cohort study on 238 patients previously hospitalized for Covid-19 pneumonia in 2020 who already underwent clinical follow-up 4 months post-Covid-19. 200 consented to participate to a 12-months clinical assessment, including: pulmonary function tests with diffusing lung capacity for carbon monoxide (DLCO); post-traumatic stress (PTS) symptoms evaluation by the Impact of Event Scale (IES); motor function evaluation (by Short Physical Performance Battery and 2 min walking test); chest Computed Tomography (CT). After 366 [363-369] days, 79 patients (39.5%) reported at least one symptom. A DLCO < 80% was observed in 96 patients (49.0%). Severe DLCO impairment (< 60%) was reported in 20 patients (10.2%), related to extent of CT scan abnormalities. Some degree of motor impairment was observed in 25.8% of subjects. 37/200 patients (18.5%) showed moderate-to-severe PTS symptoms. In the time elapsed from 4 to 12 months after hospital discharge, motor function improves, while respiratory function does not, being accompanied by evidence of lung structural damage. Symptoms remain highly prevalent one year after acute illness.
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