Synthesis, characterization and antitumor activity of novel ferrocene bisamide derivatives containing pyrimidine-moiety

被引:19
作者
Guo, Ying [1 ]
Wang, Si-Qi [2 ]
Ding, Zong-Qing [1 ]
Zhou, Jia [1 ]
Ruan, Ban-Feng [2 ]
机构
[1] Haijiang Normal Univ, Dept Biol Chem & Environm Engn, Shiyan 442500, Peoples R China
[2] Hefei Univ Technol, Sch Biol & Med Engn, Hefei 230009, Anhui, Peoples R China
关键词
Ferrocene derivative; Pyrimidine-moiety; X-ray structural analysis; Antitumor activity; Cell apoptosis; ANTICANCER ACTIVITY; MOLECULAR-MECHANISMS; BIOLOGICAL-ACTIVITY; CRYSTAL-STRUCTURE; COMPLEXES; CISPLATIN; CANCER; BINDING; CHEMOTHERAPY; PRECURSORS;
D O I
10.1016/j.jorganchem.2017.09.032
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Starting from two ferrocene-based pyrimidinamines (3 and 8), two series of novel ferrocene bisamide derivatives (4a-m and 9a-m) were synthesized and characterized, respectively. Both 3 and 8 gave single crystals suitable for X-ray structural analysis. All the corresponding bisamide derivatives were evaluated the inhibitory activities against B16-F10 and A549 cell lines using the MTT method. Among them, compound 4d exhibited comparable antitumor activities in vitro against B16-F10 and compound 9d exhibited significant antitumor activities in vitro against A549. Cancer cell apoptosis assay were performed and results indicated that compound 9d effectively fuels A549 cells apoptosis in a dosedependent manner. (C) 2017 Elsevier B. V. All rights reserved.
引用
收藏
页码:150 / 159
页数:10
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