Microwave-Assisted Fluorous Multicomponent Reactions - A Combinatorial Chemistry Approach for Green Organic Synthesis

被引：12
作者：
Kadam, Asha [1 ]
Zhang, Zijuan [1 ]
Zhang, Wei [1 ]
机构：
[1] Univ Massachusetts, Dept Chem, Boston, MA 02125 USA
来源：
CURRENT ORGANIC SYNTHESIS | 2011年 / 8卷 / 02期
关键词：
Fluorous synthesis; microwave reactions; multicomponent reactions; combinatorial chemistry; green chemistry; SOLUTION-PHASE SYNTHESIS; 1,3-DIPOLAR CYCLOADDITION; ONE-POT; PARALLEL SYNTHESIS; UGI; BENZIMIDAZOLES; GENERATION; ISOCYANIDE; LIBRARIES; PYRAZINES;
D O I：
10.2174/157017911794697259
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The development of combinatorial chemistry has significantly improved the efficiency of compound library synthesis for high-throughput screening. This technology could also be used to address the green chemistry concerns in organic synthesis. The combination of microwave reactions, multicomponent reactions, and fluorous separations to synthesize organic compounds described in this paper have demonstrated the advantages of energy efficiency, atom economy, easy purification, and reduced amount of waste solvents.
引用
收藏
页码：295 / 309
页数：15
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