Neopterin: From Forgotten Biomarker to Leading Actor in Cardiovascular Pathophysiology

被引:48
作者
De Rosa, Salvatore [1 ]
Cirillo, Plinio [1 ]
Pacileo, Mario [1 ]
Petrillo, Gianluca [1 ]
D'Ascoli, Greta-Luana [1 ]
Maresca, Fabio [1 ]
Ziviello, Francesca [1 ]
Chiariello, Massimo [1 ]
机构
[1] Univ Naples Federico II, Dept Internal Med Cardiovasc & Immunol Sci, Div Cardiol, I-80131 Naples, Italy
关键词
Atherosclerosis; cardiovascular disease; inflammation; neopterin; C-REACTIVE PROTEIN; PERIPHERAL ARTERIAL-DISEASE; NECROSIS-FACTOR-ALPHA; INTERCELLULAR-ADHESION MOLECULE-1; NITRIC-OXIDE SYNTHASE; LEFT-VENTRICULAR DYSFUNCTION; COA REDUCTASE INHIBITORS; ACUTE CORONARY SYNDROME; ADVERSE CARDIAC EVENTS; FACTOR-KAPPA-B;
D O I
10.2174/157016111794519372
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Inflammation plays a role at all stages of atherosclerosis. Neopterin, a pteridine mainly synthesized by activated macrophages, is a marker of inflammation, immune system activation and an active participant in cardiovascular disease. Measurement of neopterin levels may help follow the evolution of specific inflammatory conditions (e. g. viral infection, renal transplant rejection, systemic inflammatory diseases, nephritic syndrome and autoimmune diseases). Serum levels of neopterin are elevated also in patients with coronary artery disease (CAD) and peripheral artery disease (PAD). Moreover, plasma levels of this molecule might predict adverse cardiovascular events in patients with CAD, acute coronary syndromes or severe PAD. In addition, neopterin levels are related to the development of heart failure. We provide an updated overview on neopterin and, its links with CAD, left ventricular dysfunction, and PAD. We also describe its potential role in cardiac regenerative strategies with using bone marrow cells.
引用
收藏
页码:188 / 199
页数:12
相关论文
共 145 条
[31]   HMG-CoA reductase inhibitors reduce nicotine-induced expression of cellular adhesion molecules in cultured human coronary endothelial cells [J].
Cirillo, Plinio ;
Pacileo, Mario ;
De Rosa, Salvatore ;
Calabro, Paolo ;
Gargiulo, Annarita ;
Angri, Valeria ;
Prevete, Nella ;
Fiorentino, Isabella ;
Ucci, Grazia ;
Sasso, Laura ;
Petrillo, Gianluca ;
D'Amore, Sergio Musto ;
Chiariello, Massimo .
JOURNAL OF VASCULAR RESEARCH, 2007, 44 (06) :460-470
[32]  
Cojocaru Inimioara Mihaela, 2007, Rom J Intern Med, V45, P365
[33]   TRANSCRIPTIONAL REGULATION OF ENDOTHELIAL-CELL ADHESION MOLECULES - NF-KAPPA-B AND CYTOKINE-INDUCIBLE ENHANCERS [J].
COLLINS, T ;
READ, MA ;
NEISH, AS ;
WHITLEY, MZ ;
THANOS, D ;
MANIATIS, T .
FASEB JOURNAL, 1995, 9 (10) :899-909
[34]   Altered kynurenine metabolism correlates with infarct volume in stroke [J].
Darlington, L. G. ;
Mackay, G. M. ;
Forrest, C. M. ;
Stoy, N. ;
George, C. ;
Stone, T. W. .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2007, 26 (08) :2211-2221
[35]   Role of endothelial dysfunction in atherosclerosis [J].
Davignon, J ;
Ganz, P .
CIRCULATION, 2004, 109 (23) :27-32
[36]   C-reactive protein and cardiovascular disease: a review of risk prediction and interventions [J].
de Ferranti, S ;
Rifai, N .
CLINICA CHIMICA ACTA, 2002, 317 (1-2) :1-15
[37]   C-reactive protein: a nontraditional serum marker of cardiovascular risk [J].
de Ferranti, Sarah D. ;
Rifai, Nader .
CARDIOVASCULAR PATHOLOGY, 2007, 16 (01) :14-21
[38]  
De Rosa S, 2010, CURR VASC PHARMACOL, V8, P259
[39]   Leptin Stimulated C-Reactive Protein Production by Human Coronary Artery Endothelial Cells [J].
De Rosa, Salvatore ;
Cirillo, Plinio ;
Pacileo, Mario ;
Di Palma, Vito ;
Paglia, Antonella ;
Chiariello, Massimo .
JOURNAL OF VASCULAR RESEARCH, 2009, 46 (06) :609-617
[40]   Evaluation of C-reactive protein measurement for assessing the risk and prognosis in ischemic stroke - A statement for health care professionals from the CRP pooling project members [J].
Di Napoli, M ;
Schwaninger, M ;
Cappelli, R ;
Ceccarelli, E ;
Di Gianfilippo, G ;
Donati, C ;
Emsley, HCA ;
Forconi, S ;
Hopkins, SJ ;
Masotti, L ;
Muir, KW ;
Paciucci, A ;
Papa, F ;
Roncacci, S ;
Sander, D ;
Sander, K ;
Smith, CJ ;
Stefanini, A ;
Weber, D .
STROKE, 2005, 36 (06) :1316-1329