Neopterin: From Forgotten Biomarker to Leading Actor in Cardiovascular Pathophysiology

被引：48

作者：

De Rosa, Salvatore ^{[1
]}

Cirillo, Plinio ^{[1
]}

Pacileo, Mario ^{[1
]}

Petrillo, Gianluca ^{[1
]}

D'Ascoli, Greta-Luana ^{[1
]}

Maresca, Fabio ^{[1
]}

Ziviello, Francesca ^{[1
]}

Chiariello, Massimo ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Internal Med Cardiovasc & Immunol Sci, Div Cardiol, I-80131 Naples, Italy

来源：

CURRENT VASCULAR PHARMACOLOGY | 2011年 / 9卷 / 02期

关键词：

Atherosclerosis; cardiovascular disease; inflammation; neopterin; C-REACTIVE PROTEIN; PERIPHERAL ARTERIAL-DISEASE; NECROSIS-FACTOR-ALPHA; INTERCELLULAR-ADHESION MOLECULE-1; NITRIC-OXIDE SYNTHASE; LEFT-VENTRICULAR DYSFUNCTION; COA REDUCTASE INHIBITORS; ACUTE CORONARY SYNDROME; ADVERSE CARDIAC EVENTS; FACTOR-KAPPA-B;

D O I：

10.2174/157016111794519372

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Inflammation plays a role at all stages of atherosclerosis. Neopterin, a pteridine mainly synthesized by activated macrophages, is a marker of inflammation, immune system activation and an active participant in cardiovascular disease. Measurement of neopterin levels may help follow the evolution of specific inflammatory conditions (e. g. viral infection, renal transplant rejection, systemic inflammatory diseases, nephritic syndrome and autoimmune diseases). Serum levels of neopterin are elevated also in patients with coronary artery disease (CAD) and peripheral artery disease (PAD). Moreover, plasma levels of this molecule might predict adverse cardiovascular events in patients with CAD, acute coronary syndromes or severe PAD. In addition, neopterin levels are related to the development of heart failure. We provide an updated overview on neopterin and, its links with CAD, left ventricular dysfunction, and PAD. We also describe its potential role in cardiac regenerative strategies with using bone marrow cells.

引用

页码：188 / 199

页数：12

共 145 条

[31] HMG-CoA reductase inhibitors reduce nicotine-induced expression of cellular adhesion molecules in cultured human coronary endothelial cells [J].