ENA/VASP proteins: Regulators of the actin cytoskeleton and cell migration

被引：530
作者：
Krause, M [1 ]
Dent, EW [1 ]
Bear, JE [1 ]
Loureiro, JJ [1 ]
Gertler, FB [1 ]
机构：
[1] MIT, Dept Biol, Cambridge, MA 02139 USA
来源：
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 2003年 / 19卷
关键词：
mena; EVL; filopodia; lamellipodia; focal adhesion;
D O I：
10.1146/annurev.cellbio.19.050103.103356
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
EnaNASP proteins are a conserved family of actin regulatory proteins made up of EVH1, EVH2 domains, and a proline-rich central region. They have been implicated in actin-based processes such as fibroblast migration, axon guidance, and T cell polarization and are important for the actin-based motility of the intracellular pathogen Listeria monocytogenes. Mechanistically, these proteins associate with barbed ends of actin filaments and antagonize filament capping by capping protein (CapZ). In addition, they reduce the density of Arp2/3-dependent actin filament branches and bind Profilin at sites of actin polymerization. Vertebrate EnaNASP proteins are substrates for PKA/PKG serine/threonine kinases. Phosphorylation by these kinases appears to modulate EnaNASP function within cells, although the mechanism underlying this regulation remains to be determined.
引用
收藏
页码：541 / 564
页数：28
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