Pulmonary surfactant: functions and molecular composition

被引：583
作者：
Goerke, J
机构：
[1] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94118 USA
[2] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94118 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 1998年 / 1408卷 / 2-3期
关键词：
dipalmitoylphosphatidylcholine; surfactant protein; surface tension; surface balance;
D O I：
10.1016/S0925-4439(98)00060-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review briefly notes recent findings important for understanding the surface mechanical functions of pulmonary surfactant. Currently known surfactant-specific proteins and lipids are discussed, with an eye to their possible functions. Competing models of the alveolar subphase life cycle of surfactant are also presented. It is concluded that, in spite of much effort, we still do not understand the basic molecular mechanisms underlying surfactant's rapid adsorption to the air-water interface. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：79 / 89
页数：11
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