Pulmonary surfactant: functions and molecular composition

被引：582
|
作者：
Goerke, J
机构：
[1] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94118 USA
[2] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94118 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 1998年 / 1408卷 / 2-3期
关键词：
dipalmitoylphosphatidylcholine; surfactant protein; surface tension; surface balance;
D O I：
10.1016/S0925-4439(98)00060-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review briefly notes recent findings important for understanding the surface mechanical functions of pulmonary surfactant. Currently known surfactant-specific proteins and lipids are discussed, with an eye to their possible functions. Competing models of the alveolar subphase life cycle of surfactant are also presented. It is concluded that, in spite of much effort, we still do not understand the basic molecular mechanisms underlying surfactant's rapid adsorption to the air-water interface. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：79 / 89
页数：11
相关论文
共 50 条
  • [21] Non-Pulmonary Immune Functions of Surfactant Proteins A and D
    Ujma, Sylvia
    Horsnell, William G. C.
    Katz, Arieh A.
    Clark, Howard W.
    Schafer, Georgia
    JOURNAL OF INNATE IMMUNITY, 2017, 9 (01) : 3 - 11
  • [22] COMPOSITION OF HUMAN PULMONARY SURFACTANT VARIES WITH EXERCISE AND LEVEL OF FITNESS
    DOYLE, R
    JONES, ME
    BARR, HA
    ORGEIG, S
    CROCKETT, AJ
    MCDONALD, CF
    NICHOLAS, TE
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1994, 149 (06) : 1619 - 1627
  • [23] Surface properties, morphology and protein composition of pulmonary surfactant subtypes
    Putman, E
    Creuwels, LAJM
    vanGolde, LMG
    Haagsman, HP
    BIOCHEMICAL JOURNAL, 1996, 320 : 599 - 605
  • [24] Surfactant proteins: Molecular genetics of neonatal pulmonary diseases
    Floros, J
    Kala, P
    ANNUAL REVIEW OF PHYSIOLOGY, 1998, 60 : 365 - 384
  • [25] Unveiling the Molecular Structure of Pulmonary Surfactant Corona on Nanoparticles
    Hu, Qinglin
    Bai, Xuan
    Hu, Guoqing
    Zuo, Yi Y.
    ACS NANO, 2017, 11 (07) : 6832 - 6842
  • [26] Molecular Impact of Conventional and Electronic Cigarettes on Pulmonary Surfactant
    Garavaglia, Maria Lisa
    Bodega, Francesca
    Porta, Cristina
    Milzani, Aldo
    Sironi, Chiara
    Dalle-Donne, Isabella
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (14)
  • [27] Molecular and functional changes of pulmonary surfactant in response to hyperoxia
    Dombrowsky, Heike
    Tschernig, Thomas
    Vieten, Gertrud
    Rau, Gunnar A.
    Ohler, Florian
    Acevedo, Christa
    Behrens, Clemens
    Poets, Christian F.
    von der Hardt, Horst
    Bernhard, Wolfgang
    PEDIATRIC PULMONOLOGY, 2006, 41 (11) : 1025 - 1039
  • [28] EFFECT OF LUNG AUTOTRANSPLANTATION HOMOTRANSPLANTATION + DENERVATION ON PULMONARY SURFACTANT STABILITY + PULMONARY FUNCTIONS OF DOGS
    GIAMMONA, ST
    DALY, WJ
    SEGAR, WE
    WALDHAUSEN, JA
    JOURNAL OF PEDIATRICS, 1964, 65 (6P2): : 1091 - +
  • [29] Multiple molecular logic functions and molecular calculations facilitated by surfactant's versatility
    Qian, Junhong
    Qian, Xuhong
    Xu, Yufang
    Zhang, Shenyi
    CHEMICAL COMMUNICATIONS, 2008, (35) : 4141 - 4143
  • [30] Phosphatidylcholine composition of pulmonary surfactant from terrestrial and marine diving mammals
    Gutierrez, Danielle B.
    Fahlman, Andreas
    Gardner, Manuela
    Kleinhenz, Danielle
    Piscitelli, Marina
    Raverty, Stephen
    Haulena, Martin
    Zimba, Paul V.
    RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 2015, 211 : 29 - 36
12345