Loss of DUSP4 Expression as a Prognostic Biomarker in Clear Cell Renal Cell Carcinoma

被引：3

作者：

Bang, Seongsik ^{[1
]}

Jee, Seungyun ^{[1
]}

Son, Hwangkyu ^{[1
]}

Wi, Young Chan ^{[2
]}

Kim, Hyunsung ^{[1
]}

Park, Hosub ^{[1
]}

Myung, Jaekyung ^{[1
]}

Shin, Su-Jin ^{[3
]}

Paik, Seung Sam ^{[1
]}

机构：

[1] Hanyang Univ, Seoul Hosp, Dept Pathol, Coll Med, Seoul 04763, South Korea

[2] Catholic Univ Korea, Dept Pathol, Eunpyeong St Marys Hosp, Seoul 03312, South Korea

[3] Yonsei Univ, Gangnam Severance Hosp, Dept Pathol, Coll Med, Seoul 06273, South Korea

来源：

DIAGNOSTICS | 2021年 / 11卷 / 10期

关键词：

renal cell carcinoma; DUSP4; dual-specificity protein phosphatase 4; prognosis; PHOSPHATASE DUSP4; IDENTIFIES DUSP4; DOWN-REGULATION; BREAST CANCERS; SURVIVAL; PROLIFERATION; PROGRESSION; DEFICIENCY; MIGRATION; INVASION;

D O I：

10.3390/diagnostics11101939

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dual-specificity protein phosphatase 4 (DUSP4) is a negative regulator of mitogen-activated protein kinases. The prognostic impact of DUSP4 expression in renal cell carcinoma is not well studied. Therefore, we evaluated the clinicopathological implications of DUSP4 expression in clear cell renal cell carcinoma by performing immunohistochemistry (IHC). The clinical outcome according to DUSP4 expression was evaluated through survival analyses, and the association between mRNA expression and prognosis was confirmed by online analysis (Kaplan-Meier plotter). Loss of DUSP4 expression was noted in most histological subtypes of renal cell carcinoma. Loss of DUSP4 expression in clear cell renal cell carcinoma was significantly correlated with old age (p = 0.033), high histologic grade (p < 0.001), tumor necrosis (p < 0.001), and high pT category (p < 0.001). In survival analysis, loss of DUSP4 expression was associated with poor clinical outcomes in cancer-specific survival and recurrence-free survival (p = 0.010 and p = 0.007, respectively). Upon TCGA data analysis, patients with low DUSP4 mRNA expression showed a shorter overall survival (p = 0.023). These results suggest that loss of DUSP4 expression can be used as a potential biomarker for predicting clinical outcomes in clear cell renal cell carcinoma patients.</p>

引用

页数：10

共 42 条

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