What makes centromeric cohesion resistant to separase cleavage during meiosis I but not during meiosis II?

被引：17
作者：
Gregan, Juraj [1 ]
Rumpf, Cornelia [1 ]
Li, Zhang [1 ]
Cipak, Lubos [1 ]
机构：
[1] Univ Vienna, Dept Biol Chem, Max Perutz Labs, A-1030 Vienna, Austria
来源：
CELL CYCLE | 2008年 / 7卷 / 02期
基金：
奥地利科学基金会;
关键词：
S; pombe; shugoshin; protein phosphatase 2A; meiosis; chromosome segregation;
D O I：
10.4161/cc.7.2.5325
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Segregation of chromosomes during meiosis I is triggered by separase cleavage of the cohesin's Rec8 subunit along chromosome arms. Centromeric cohesin is protected from separase cleavage during meiosis I by Sgo1/MEI-S332 proteins in complex with protein phosphatase 2A (PP2A). This retention of centromeric sister chromatid cohesion is essential for faithful segregation of chromatids during the second meiotic division. While Sgo1/PP2A complex is required for protecting centromeric sister chromatid cohesion during meiosis I, it is not known what renders the centromeric cohesion sensitive to separase cleavage during meiosis II. Our data suggest that the absence of Sgo1 and PP2A from meiosis II centromeres is not sufficient to render centromeric cohesion sensitive to cleavage by separase and additional factors are required to ensure the removal of centromeric cohesion during meiosis II.
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收藏
页码：151 / 153
页数：3
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