Isolation and genetic characterization of novel reassortant H6N6 subtype avian influenza viruses isolated from chickens in eastern China

被引：15

作者：

Wu, Haibo ^{[1
]}

Lu, Rufeng ^{[2
]}

Peng, Xiuming ^{[1
]}

Peng, Xiaorong ^{[1
]}

Cheng, Linfang ^{[1
]}

Jin, Changzhong ^{[1
]}

Lu, Xiangyun ^{[1
]}

Xie, Tiansheng ^{[1
]}

Yao, Hangping ^{[1
]}

Wu, Nanping ^{[1
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 1, State Key Lab Diag & Treatment Infect Dis,Sch Med, Collaborat Innovat Ctr Diag & Treatment Infect Di, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China

[2] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Dept Emergency, Hangzhou 310006, Zhejiang, Peoples R China

来源：

ARCHIVES OF VIROLOGY | 2016年 / 161卷 / 07期

基金：

美国国家科学基金会;

关键词：

A H7N9 VIRUS; RECEPTOR-BINDING; DOMESTIC DUCKS; MOLECULAR CHARACTERIZATION; PHYLOGENETIC ANALYSIS; ZHEJIANG PROVINCE; POULTRY; EVOLUTION; INFECTION; PATHOGENICITY;

D O I：

10.1007/s00705-016-2861-4

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

H6 subtype avian influenza viruses (AIVs) possess the ability to cross the species barrier to infect mammals and pose a threat to human health. From June 2014 to July 2015, 12 H6N6 AIVs were isolated from chickens in live-poultry markets in Zhejiang Province, Eastern China. Phylogenetic analysis showed that these isolates received their genes from H6 and H9N2 subtype AIVs of poultry in China. These novel reassortant viruses showed moderate pathogenicity in mice and were able to replicate in mice without prior adaptation. Considering that novel reassorted H6N6 viruses were isolated from chickens in this study, it is possible that these chickens play an important role in the generation of novel reassorted H6N6 AIVs, and these results emphasize the need for continued surveillance of the H6N6 AIVs circulating in poultry.

引用

页码：1859 / 1872

页数：14

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