PRC2 activity, recruitment, and silencing: a comparative perspective

被引：50

作者：

Bieluszewski, Tomasz ^{[1
]}

Xiao, Jun ^{[2
,3
]}

Yang, Yiman ^{[2
,4
]}

Wagner, Doris ^{[1
]}

机构：

[1] Univ Penn, Dept Biol, Philadelphia, PA 19103 USA

[2] Chinese Acad Sci, Innovat Acad Seed Design, Inst Genet & Dev Biol, State Key Lab Plant Cell & Chromosome Engn, Beijing 100101, Peoples R China

[3] John Innes Ctr, Ctr Excellence Plant & Microbial Sci CEPAMS, Norwich Res Pk, Norwich NR4 7UH, Norfolk, England

[4] Nanjing Agr Univ, Coll Hort, Nanjing 210095, Peoples R China

来源：

TRENDS IN PLANT SCIENCE | 2021年 / 26卷 / 11期

基金：

美国国家科学基金会;

关键词：

POLYCOMB-GROUP PROTEINS; REPRESSIVE COMPLEX 1; FLORAL TRANSITION; PHASE-SEPARATION; RNA-BINDING; CHROMATIN; FLC; VERNALIZATION; METHYLATION; NUCLEOSOME;

D O I：

10.1016/j.tplants.2021.06.006

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Polycomb repressive complex (PRC)-mediated gene silencing is vital for cell identity and development in both the plant and the animal kingdoms. It also modulates responses to stress. Two major protein complexes, PRC1 and PRC2, execute conserved nuclear functions in metazoans and plants through covalent modification of histones and by compacting chromatin. While a general requirement for Polycomb complexes in mitotically heritable gene repression in the context of chromatin is well established, recent studies have brought new insights into the regulation of Polycomb complex activity and recruitment. Here, we discuss these recent advances with emphasis on PRC2.

引用

收藏

页码：1186 / 1198

页数：13

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