A Near-Infrared Fluorescence Probe for Thiols Based on Analyte-Specific Cleavage of Carbamate and Its Application in Bioimaging

被引：33

作者：

Zhang, Jianjian ^{[1
,2
]}

Yu, Bianfei ^{[1
,2
]}

Ning, Lulu ^{[1
,2
]}

Zhu, Xinyue ^{[1
,2
]}

Wang, Jianxi ^{[1
,2
]}

Chen, Zhenjie ^{[3
]}

Liu, Xiaoyan ^{[1
,2
]}

Yao, Xiaojun ^{[1
,2
]}

Zhang, Xiaoyu ^{[3
]}

Zhang, Haixia ^{[1
,2
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China

[2] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China

[3] Lanzhou Univ, Inst Physiol, Sch Basic Med Sci, Lanzhou 730000, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 2015卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Dyes; pigments; Imaging agents; Fluorescent probes; Cyanines; Thiols; RECENT PROGRESS; COLORIMETRIC CHEMOSENSORS; SELECTIVE DETECTION; OXIDATIVE STRESS; GLUTATHIONE; CYSTEINE; HOMOCYSTEINE; LUMINESCENT; SENSORS; DESIGN;

D O I：

10.1002/ejoc.201403398

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

With increasing interest in optical in vivo imaging, there is a corresponding increase in demand for near-infrared (NIR) dyes. Such probes can be used, for example, to detect intracellular GSH, which would be helpful for understanding the mechanisms of diseases. In this work, we report a cyanine-based fluorescent probe that undergoes biothiol-promoted specific O-S cleavage and subsequent self-immolation through intramolecular 1,6-elimination. In addition, we investigated the cell viability of the system and successfully applied the probe to living cells, in vivo, and in various tissues.

引用

页码：1711 / 1718

页数：8

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