Three New Terpenoid Indole Alkaloids from Catharanthus roseus

被引：21
|
作者：
Wang, Lei [1 ,2 ]
Zhang, Yu [1 ]
He, Hong-Ping [1 ]
Zhang, Qiang [1 ]
Li, Shi-Fei [1 ,2 ]
Hao, Xiao-Jiang [1 ]
机构：
[1] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
来源：
PLANTA MEDICA | 2011年 / 77卷 / 07期
基金：
中国国家自然科学基金;
关键词：
Catharanthus roseus (L.) G. Don; Apocynaceae; terpenoid indole alkaloids; vidolicine; normacusine B N-oxide; lochnerine N-oxide; cytotoxic activity; LEAVES;
D O I：
10.1055/s-0030-1250569
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Three new terpenoid indole alkaloids, vidolicine (1), normacusine B N-oxide (2), and lochnerine N-oxide (3), together with seven known ones (410), were isolated from whole plants of Catharanthus roseus. Their structures were elucidated by spectroscopic methods (NMR, MS, UV, and IR). Cytotoxic activities of these isolates (1-10) were evaluated, but only compound 8 was active against HL-60, SMMC-7721, and A549 cell lines.
引用
收藏
页码：754 / 758
页数：5
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