Optimizing surface-plasmon resonance sensors for limit of detection based on a Cramer-Rao bound

被引：15

作者：

Hastings, J. T. ^{[1
]}

机构：

[1] Univ Kentucky, Dept Elect & Comp Engn, Lexington, KY 40506 USA

来源：

IEEE SENSORS JOURNAL | 2008年 / 8卷 / 1-2期

基金：

美国国家科学基金会;

关键词：

biochemical sensing; optical sensing; spectral analysis; surface plasmons;

D O I：

10.1109/JSEN.2007.912782

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

This paper addresses the optimization of prism-coupled, wavelength-interrogated surface-plasmon resonance (SPR) sensors. Limit of detection (LOD), rather than sensitivity, is chosen as a figure of merit. The Cramer-Rao bound (CRB) for spectral shift estimation allows lower bounds to be placed on LOD independent of interrogation system and estimation algorithm. Analytic evaluation of the CRB for a Lorentzian spectral feature justifies common observations about the relationship between resonance line shape and sensor performance. Numerical evaluation of standard SPR sensor configurations shows that maximizing sensitivity is an insufficient criterion for minimizing limit of detection. Designs optimized for LOD are presented for common SPR sensor materials and geometries.

引用

页码：170 / 175

页数：6

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