Segmentation of breast ultrasound image with semantic classification of superpixels

Breast cancer is a great threat to females. Ultrasound imaging has been applied extensively in diagnosis of breast cancer. Due to the poor image quality, segmentation of breast ultrasound (BUS) image remains a very challenging task. Besides, BUS image segmentation is a crucial step for further analysis. In this paper, we proposed a novel method to segment the breast tumor via semantic classification and merging patches. The proposed method firstly selects two diagonal points to crop a region of interest (ROI) on the original image. Then, histogram equalization, bilateral filter and pyramid mean shift filter are adopted to enhance the image. The cropped image is divided into many superpixels using simple linear iterative clustering (SLIC). Furthermore, some features are extracted from the superpixels and a bag-of-words model can be created. The initial classification can be obtained by a back propagation neural network (BPNN). To refine preliminary result, k-nearest neighbor (KNN) is used for reclassification and the final result is achieved. To verify the proposed method, we collected a BUS dataset containing 320 cases. The segmentation results of our method have been compared with the corresponding results obtained by five existing approaches. The experimental results show that our method achieved competitive results compared to conventional methods in terms of TP and FP, and produced good approximations to the hand-labelled tumor contours with comprehensive consideration of all metrics (the F1-score = 89.87% +/- 4.05%, and the average radial error = 9.95% +/- 4.42%). (C) 2020 Elsevier B.V. All rights reserved.