An Efficient Diphosphine/Hybrid-Amine Combination for Ruthenium(II)-Catalyzed Asymmetric Hydrogenation of Aryl Ketones

被引：38

作者：

Li, Yuehui ^{[1
]}

Zhou, Yougui ^{[2
]}

Shi, Qixun ^{[1
]}

Ding, Kuiling ^{[1
]}

Noyori, Ryoji ^{[3
,4
]}

Sandoval, Christian A. ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

[2] Enantiotech Corp Ltd, Zhongshan Torch Hi Tech Ind Dev Zone, Zhongshan, Guangdong, Peoples R China

[3] Nagoya Univ, Dept Chem, Nagoya, Aichi 4648601, Japan

[4] Nagoya Univ, Res Ctr Mat Sci, Nagoya, Aichi 4648601, Japan

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2011年 / 353卷 / 2-3期

基金：

中国国家自然科学基金;

关键词：

alcohols; asymmetric catalysis; hydrogenation; N ligands; ruthenium; LIGAND BIFUNCTIONAL CATALYSIS; RUTHENIUM HYDRIDE COMPLEXES; CARBONYL-COMPOUNDS; BINAP/1,2-DIAMINE-RUTHENIUM(II) COMPLEXES; ENANTIOSELECTIVE HYDROGENATION; STEREOSELECTIVE HYDROGENATION; AMINOPHOSPHINE LIGANDS; AROMATIC KETONES; ALKYL KETONES; REDUCTION;

D O I：

10.1002/adsc.201000577

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Readily available and modular hybrid amine/benzimidazole-based 1H-benzimidazole-2-methanamine (BIMA) ligands in combination with 2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino) butane (DIOP) afford efficient catalytic systems for the ruthenium(II)-catalyzed asymmetric hydrogenation (AH) of a number of aryl ketones. The AH proceeds smoothly with substrate-to-catalyst (S/C) molar ratios of up to 100,000 (TOF of 6500 h(-1), 8 atm) giving chiral alcohols in up to 99% ee.

引用

页码：495 / 500

页数：6

共 53 条

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